Evidence map›Paper›PMID 36627487›Full record

ReviewNature reviews. Urology2023

Lessons learned from the first 15 years of penile transplantation and updates to the Baltimore Criteria.

Christopher D Lopez, Alisa O Girard, Isabel V Lake, Byoung Chol Oh, Gerald Brandacher, Damon S Cooney, Arthur L Burnett, Richard J Redett

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Christopher D LopezDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MA, USA.
Alisa O GirardDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MA, USA.
Isabel V LakeDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MA, USA.
Byoung Chol OhDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MA, USA.
Gerald BrandacherDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MA, USA.
Damon S CooneyDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MA, USA.
Arthur L BurnettDepartment of Urology, Johns Hopkins University School of Medicine, Baltimore, MA, USA.
Richard J RedettDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MA, USA. rjr@jhmi.edu.ORCID 0000-0002-0082-5972
Johns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since 2006, five penis transplants have been performed worldwide. Mixed outcomes have been reported, and two of the five penile transplants have required explantation. However, the long-term outcomes have been encouraging when compliance is implemented, whether standard induction and triple therapy maintenance, or single therapy maintenance. Follow-up monitoring of transplant recipients has enabled a synthesis of technical considerations for surgical success and has shown stable leukocyte counts and renal function after a donor bone-marrow-based immunomodulatory regimen followed by tacrolimus monotherapy as long as 3 years post-transplant, as well as continuous nerve regeneration of penile allografts 3 years post-transplant. Areas of uncertainty include the ethics of donor-recipient colour mismatch, surveillance for sexually transmitted infections and how to optimize patient compliance. Questions also remain with respect to the long-term immunological sequelae of penile tissue, functional outcomes, psychosocial implications and patient selection. Patient counselling should be modified to mention the possibility of long-term improvement in nerve regeneration and sufficient renal function with single-therapy maintenance, and to build a longitudinal dialogue and partnership between the patient and the multidisciplinary care team regarding the risks of sexually transmitted infection instead of surveillance.

Indexed as

Penile TransplantationTacrolimusBaltimoreHumansMalePenisTissue DonorsTacrolimus

Identifiers

PMID36627487
PMCPMC9838304
OpenAlexW4314434854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.