ArticleNature communications2023
Choice selective inhibition drives stability and competition in decision circuits.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Disinhibitory signaling enables flexible coding of top-down information in cortical networks.PLoS biology · 2026Article
- Prefrontal parvalbumin neurons as a target for enhancing cognition in non-pathological and 22q11.2 microdeletion syndrome mice.Molecular psychiatry · 2026Article
- Limitations of Variational Laplace-Based Dynamic Causal Modelling for Multistable Cortical Circuits.Neuroinformatics · 2026Article
- Neural circuit models for evidence accumulation through choice-selective sequences.Nature communications · 2026Article
- Data-derived agents reveal dynamical reservoirs in mouse cortex for adaptive behavior.bioRxiv : the preprint server for biology · 2026Article
- Article
- Neural Oscillation as a Selective Modulatory Mechanism on Decision Confidence, Speed, and Accuracy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A neural circuit framework for economic choice: from building blocks of valuation to compositionality in multitasking.bioRxiv : the preprint server for biology · 2025Article
- Diverse and flexible behavioral strategies arise in recurrent neural networks trained on multisensory decision making.PLoS computational biology · 2025Article
- Article
- Large-scale maps of altered cortical dynamics in early-stage psychosis are related to GABAergic and glutamatergic neurotransmission.Science advances · 2025Article
- Feature-specific inhibitory connectivity augments the accuracy of cortical representations.bioRxiv : the preprint server for biology · 2025Article
- Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques.Communications biology · 2025Article
- Cell-type specific sensory and motor activity in the cuneiform nucleus and pedunculopontine nucleus in mice.Scientific reports · 2025Article
- Neural mechanisms balancing accuracy and flexibility in working memory and decision tasks.NPJ systems biology and applications · 2025Article
- Single-unit activations confer inductive biases for emergent circuit solutions to cognitive tasks.Nature machine intelligence · 2025Article
- Flexible gating between subspaces in a neural network model of internally guided task switching.Nature communications · 2024Article
- Flexible gating between subspaces in a neural network model of internally guided task switching.bioRxiv : the preprint server for biology · 2024Article
- Dopamine-sensitive neurons in the mesencephalic locomotor region control locomotion initiation, stop, and turns.Cell reports · 2024Article
- Learning to Choose: Behavioral Dynamics Underlying the Initial Acquisition of Decision-Making.eNeuro · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
During perceptual decision-making, the firing rates of cortical neurons reflect upcoming choices. Recent work showed that excitatory and inhibitory neurons are equally selective for choice. However, the functional consequences of inhibitory choice selectivity in decision-making circuits are unknown. We developed a circuit model of decision-making which accounts for the specificity of inputs to and outputs from inhibitory neurons. We found that selective inhibition expands the space of circuits supporting decision-making, allowing for weaker or stronger recurrent excitation when connected in a competitive or feedback motif. The specificity of inhibitory outputs sets the trade-off between speed and accuracy of decisions by either stabilizing or destabilizing the saddle-point dynamics underlying decisions in the circuit. Recurrent neural networks trained to make decisions display the same dependence on inhibitory specificity and the strength of recurrent excitation. Our results reveal two concurrent roles for selective inhibition in decision-making circuits: stabilizing strongly connected excitatory populations and maximizing competition between oppositely selective populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.