ArticleGut2023
Gestational diabetes is driven by microbiota-induced inflammation months before diagnosis.
Article in Gut, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
103 citing papers in PubMed, 2 syntheses or guidelines pooled it, 142 citations in OpenAlex.
- Cellular and Molecular Pathophysiology of Gestational Diabetes.International journal of molecular sciences · 2024Pooled it
- Relationship between gut microbiota and the pathogenesis of gestational diabetes mellitus: a systematic review.Frontiers in cellular and infection microbiology · 2024Pooled it
- Imbalance of gut microbiota in gestational diabetes.BMC pregnancy and childbirth · 2024Trial
- Gut microbiome and pregnancy complications: emerging evidence and mechanistic insights.Gut microbes · 2026Review
- Mapping current evidence and knowledge gaps in gestational diabetes mellitus in Vietnam and Vietnamese diaspora: a scoping review.Global health action · 2026Article
- Gardnerella enrichment in the vaginal microbiome of women with gestational diabetes mellitus is associated with lower fetal birthweight percentiles.Diabetologia · 2026Observational
- A three-metabolite microbiota-associated signature for early risk stratification of gestational diabetes mellitus.Cardiovascular diabetology · 2026Article
- Maternal and infant gut microbiome.iMeta · 2026Review
- A gut microbiome-lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk.iMeta · 2026Article
- MMP8 Promotes NETosis in Gestational Diabetes Mellitus.Antioxidants (Basel, Switzerland) · 2026Article
- Advancing Personalized Medicine in Gestational Diabetes Mellitus Management Through Gut Microbiota Insights.International journal of molecular sciences · 2026Review
- Maternal Microbiome in Gestational Diabetes Mellitus: Mechanisms, Biomarkers, and Therapeutic Perspectives.Life (Basel, Switzerland) · 2026Review
- Gestational diabetes mellitus and maternal-infant microbiome axis: mechanistic insights and therapeutic interventions.Journal of translational medicine · 2026Review
- Galacto-oligosaccharides enrich galactosidase-encoded rather than all Lachnospiraceae bacteria to redress abnormal gut microbiota and lipid metabolism in pregnancy.Science China. Life sciences · 2026Article
- Inflammation at the Maternal-Fetal Interface: Mechanisms Linking Maternal-Fetal Immunity to Preeclampsia and Fetal Growth Restriction.International journal of molecular sciences · 2026Review
- A Review of Gut Microbiota Dynamics: From Healthy Gestation to Gestational Diabetes in Human and Mouse Models.Biomedicines · 2026Review
- LASSO regression-derived first-trimester (9-14Archives of gynecology and obstetrics · 2026Article
- Urine Metabolism Biomarkers Predict Preterm Infant Adiposity at Hospital Discharge.Molecular nutrition & food research · 2026Article
- Gut microbiota dysbiosis, circulating microbial genetic traces, and their role in gestational diabetes.World journal of diabetes · 2026Review
- Intestinal fungal dysbiosis in gestational diabetes mellitus is associated with adverse pregnancy outcomes.BMC pregnancy and childbirth · 2026Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 11 institutions in 4 countries.
Funding
Abstract
objectiveGestational diabetes mellitus (GDM) is a condition in which women without diabetes are diagnosed with glucose intolerance during pregnancy, typically in the second or third trimester. Early diagnosis, along with a better understanding of its pathophysiology during the first trimester of pregnancy, may be effective in reducing incidence and associated short-term and long-term morbidities.
designWe comprehensively profiled the gut microbiome, metabolome, inflammatory cytokines, nutrition and clinical records of 394 women during the first trimester of pregnancy, before GDM diagnosis. We then built a model that can predict GDM onset weeks before it is typically diagnosed. Further, we demonstrated the role of the microbiome in disease using faecal microbiota transplant (FMT) of first trimester samples from pregnant women across three unique cohorts.
resultsWe found elevated levels of proinflammatory cytokines in women who later developed GDM, decreased faecal short-chain fatty acids and altered microbiome. We next confirmed that differences in GDM-associated microbial composition during the first trimester drove inflammation and insulin resistance more than 10 weeks prior to GDM diagnosis using FMT experiments. Following these observations, we used a machine learning approach to predict GDM based on first trimester clinical, microbial and inflammatory markers with high accuracy.
conclusionGDM onset can be identified in the first trimester of pregnancy, earlier than currently accepted. Furthermore, the gut microbiome appears to play a role in inflammation-induced GDM pathogenesis, with interleukin-6 as a potential contributor to pathogenesis. Potential GDM markers, including microbiota, can serve as targets for early diagnostics and therapeutic intervention leading to prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.