Evidence map›Paper›PMID 36627144›Full record

ArticleJournal for immunotherapy of cancer2023

Tumor-infiltrating lymphocytes mediate complete and durable remission in a patient with NY-ESO-1 expressing prostate cancer.

Julia Karbach, Dragan Kiselicki, Kathrin Brand, Claudia Wahle, Evgueni Sinelnikov, Dirk Gustavus, Hans Hoffmeister, Hans-Bernd Prisack, Akin Atmaca, Elke Jäger

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal for immunotherapy of cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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  12. CD8Journal of translational medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Julia KarbachOncology and Hematology, Krankenhaus Nordwest, Frankfurt, Germany ej200161@aol.com.
Dragan KiselickiOncology and Hematology, Krankenhaus Nordwest, Frankfurt, Germany ej200161@aol.com.
Kathrin BrandOncology and Hematology, Krankenhaus Nordwest, Frankfurt, Germany ej200161@aol.com.
Claudia WahleOncology and Hematology, Krankenhaus Nordwest, Frankfurt, Germany ej200161@aol.com.
Evgueni SinelnikovZellwerk GmbH, Oberkrämer, Germany.
Dirk GustavusZellwerk GmbH, Oberkrämer, Germany.
Hans HoffmeisterZellwerk GmbH, Oberkrämer, Germany.
Hans-Bernd PrisackNextGen Oncology, Düsseldorf, Germany.
Akin AtmacaOncology and Hematology, Krankenhaus Nordwest, Frankfurt, Germany ej200161@aol.com.
Elke JägerOncology and Hematology, Krankenhaus Nordwest, Frankfurt, Germany ej200161@aol.com.
Krankenhaus Nordwest · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adoptive transfer of autologous tumor-specific lymphocytes represents a viable treatment method for patients with advanced malignancies. Here, we report a patient's case with metastatic hormone-refractory New York esophageal squamous cell carcinoma 1 (NY-ESO-1) expressing prostate cancer treated with in vitro expanded tumor-infiltrating lymphocytes (TILs) in conjunction with IL-2 and immune-checkpoint blockade. Complete and durable tumor remission was observed after three TIL infusions consisting of 1.4×10

Indexed as

Esophageal NeoplasmsEsophageal Squamous Cell CarcinomaProstatic NeoplasmsAntibodiesHumansLymphocytes, Tumor-InfiltratingMaleRepressor ProteinsT-LymphocytesAntibodiesRepressor ProteinsTRPS1 protein, humanCell EngineeringImmunotherapy, AdoptiveLymphocytes, Tumor-Infiltrating

Identifiers

PMID36627144
PMCPMC9835940
OpenAlexW4313989896

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.