Evidence map›Paper›PMID 36627027›Full record

ArticleDiabetes research and clinical practice2023

Longitudinal trends in glycated hemoglobin during and after tuberculosis treatment.

Hardy Kornfeld, Elizabeth Procter-Gray, Satyavani Kumpatla, Kevin Kane, Wenjun Li, Matthew J Magee, Subash Babu, Vijay Viswanathan

Abstract read
In one paragraph

Article in Diabetes research and clinical practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Hardy KornfeldDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. Electronic address: Hardy.Kornfeld@umassmed.edu.
Elizabeth Procter-GrayDepartment of Public Health, University of Massachusetts Lowell, Lowell, MA, USA.
Satyavani KumpatlaProf. M. Viswanathan Diabetes Research Centre, Chennai, India.
Kevin KaneDepartment of Public Health, University of Massachusetts Lowell, Lowell, MA, USA.
Wenjun LiDepartment of Public Health, University of Massachusetts Lowell, Lowell, MA, USA.
Matthew J MageeDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Subash BabuNational Institute for Research in Tuberculosis, International Center for Excellence in Research, National Institutes of Health, Chennai, India.
Vijay ViswanathanProf. M. Viswanathan Diabetes Research Centre, Chennai, India.
University of Massachusetts Lowell · USIndia Diabetes Research Foundation · INEmory University · USNational Institute of Research in Tuberculosis · IN

Funding

India International Center for Excellence in ResearchZIAAI001065 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NUTMAN, THOMAS · 2009 to 2025
$19.0M
Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · NIAID · EMORY UNIVERSITY · PI Jeffrey M Collins · 2022 to 2026
$5.8M
Immunometabolic impact of stress hyperglycemia on tuberculosis treatment outcomes and risk of diabetes mellitusR01AI153152 · NIAID · EMORY UNIVERSITY · PI MAGEE, MATTHEW JAMES · 2021 to 2025
$3.7M
NIAID NIH HHS P30 AI168386NIAID NIH HHS R01 AI153152
6 · The paper itself

Abstract

aimsTo investigate the impact of pulmonary TB on glycemic status during and after TB treatment, and associations of glycemic trends with antidiabetic therapy and TB outcomes.

methodsData from two prospective cohort studies of adults in Chennai, India, with pulmonary TB were combined for this analysis. Participants were classified by baseline hemoglobin A1

resultsMedian A1C at baseline declined after TB treatment initiation in all groups. No baseline NG or pre-DM participants progressed to DM by end of study, while 16.7% of baseline DM participants shifted to pre-DM or NG levels of A1C. In the baseline DM group, rising A1C after the intensive phase of TB treatment was significantly associated with adverse TB outcomes.

conclusionsIncident TB promotes transient glucose elevation but was not conclusively shown to promote chronic dysglycemia. Rising A1C during and after TB treatment may predict unfavorable treatment response in persons presenting with A1C ≥ 6.5 % at the time of TB diagnosis.

Indexed as

Diabetes MellitusTuberculosis, PulmonaryAdultBlood GlucoseGlycated HemoglobinHumansIndiaProspective StudiesBlood GlucoseGlycated HemoglobinDiabetesGlycated hemoglobinGlycemic controlPrediabetesStress hyperglycemiaTuberculosis

Identifiers

PMID36627027
PMCPMC13282844
OpenAlexW4313680896

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.