Evidence map›Paper›PMID 36626722›Full record

ReviewJournal of proteome research2023

Proteomics Standards Initiative at Twenty Years: Current Activities and Future Work.

Eric W Deutsch, Juan Antonio Vizcaíno, Andrew R Jones, Pierre-Alain Binz, Henry Lam, Joshua Klein, Wout Bittremieux, Yasset Perez-Riverol, David L Tabb, Mathias Walzer and 19 more

Abstract readReview
In one paragraph

Review in Journal of proteome research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A systematic review and in silico analysis of studies investigating the ischemic penumbra proteome in animal models of experimental stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Interactomics: Dissecting Protein Networks in Living Systems.Advances in experimental medicine and biology · 2026
    Review
  14. Challenges and Opportunities for Statistics in Omics Data Analysis.Advances in experimental medicine and biology · 2026
    Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. What Have Data Standards Ever Done for Us?Molecular & cellular proteomics : MCP · 2025
    Review
  20. Open-Source and FAIR Research Software for Proteomics.Journal of proteome research · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Eric W DeutschInstitute for Systems Biology, Seattle, Washington 98109, United States.ORCID 0000-0001-8732-0928
Juan Antonio VizcaínoEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.ORCID 0000-0002-3905-4335
Andrew R JonesInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, United Kingdom.ORCID 0000-0001-6118-9327
Pierre-Alain BinzClinical Chemistry Service, Lausanne University Hospital, 1011 976 Lausanne, Switzerland.
Henry LamDepartment of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong 999077, P. R. China.ORCID 0000-0001-7928-0364
Joshua KleinProgram for Bioinformatics, Boston University, Boston, Massachusetts 02215, United States.
Wout BittremieuxSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0002-3105-1359
Yasset Perez-RiverolEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.ORCID 0000-0001-6579-6941
David L TabbSA MRC Centre for TB Research, DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7602, South Africa.ORCID 0000-0001-7223-578X
Mathias WalzerEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.ORCID 0000-0003-4538-2754
Sylvie Ricard-BlumUniv. Lyon, Université Lyon 1, ICBMS, UMR 5246, 69622 Villeurbanne, France.ORCID 0000-0001-9263-1851
Henning HermjakobEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.ORCID 0000-0001-8479-0262
Steffen NeumannBioinformatics and Scientific Data, Leibniz Institute of Plant Biochemistry, 06120 Halle, Germany.ORCID 0000-0002-7899-7192
Tytus D MakMass Spectrometry Data Center, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, Maryland 20899, United States.ORCID 0000-0001-9501-5640
Shin KawanoDatabase Center for Life Science, Joint Support Center for Data Science Research, Research Organization of Information and Systems, Chiba 277-0871, Japan.ORCID 0000-0002-7969-2972
Luis MendozaInstitute for Systems Biology, Seattle, Washington 98109, United States.ORCID 0000-0003-0128-8643
Tim Van Den BosscheVIB-UGent Center for Medical Biotechnology, VIB, 9052 Ghent, Belgium.
Ralf GabrielsVIB-UGent Center for Medical Biotechnology, VIB, 9052 Ghent, Belgium.ORCID 0000-0002-1679-1711
Nuno BandeiraSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0001-8385-3655
Jeremy CarverCenter for Computational Mass Spectrometry, Department of Computer Science and Engineering, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego 92093-0404, United States.ORCID 0000-0003-0384-8130
Benjamin PullmanCenter for Computational Mass Spectrometry, Department of Computer Science and Engineering, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego 92093-0404, United States.ORCID 0000-0002-2733-4911
Zhi SunInstitute for Systems Biology, Seattle, Washington 98109, United States.ORCID 0000-0003-3324-6851
Nils HoffmannInstitute for Bio- and Geosciences (IBG-5), Forschungszentrum Jülich GmbH, 52428 Jülich, Germany.ORCID 0000-0002-6540-6875
Jim ShofstahlThermo Fisher Scientific, 355 River Oaks Parkway, San Jose, California 95134, United States.
Yunping ZhuNational Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, #38, Life Science Park, Changping District, Beijing 102206, China.ORCID 0000-0002-7320-7411
Luana LicataFondazione Human Technopole, 20157 Milan, Italy.ORCID 0000-0001-5084-9000
Federica QuagliaInstitute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council (CNR-IBIOM), 70126 Bari, Italy.
Silvio C E TosattoDepartment of Biomedical Sciences, University of Padova, 35131 Padova, Italy.ORCID 0000-0003-4525-7793
Sandra E OrchardEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.ORCID 0000-0002-8878-3972

Funding

Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI Thomas Girke, NICHOLAS Joseph SCHORK · 2004 to 2026
$102.6M
UniProt - Text Mining and Large Language models to Enhance Functional Annotation in UniProt of Protein Variants Associated with Alzheimer's DiseaseU24HG007822 · NHGRI · GEORGETOWN UNIVERSITY · PI Alex Bateman, Alan James Bridge · 2018 to 2026
$53.0M
Shortening the development cycle time of Trans Proteomic Pipeline tools with high performance computingR01GM087221 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI DEUTSCH, ERIC, MORITZ, ROBERT L · 2010 to 2021
$6.0M
MassIVE.quant: a curated and scalable community resource for quantitative proteomicsR01LM013115 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BANDEIRA, NUNO · 2019 to 2022
$1.3M
Advancing data and metadata standards for proteomics mass spectraR24GM127667 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI DEUTSCH, ERIC · 2017 to 2019
$1.2M
Biotechnology and Biological Sciences Research Council BB/K01997X/1Biotechnology and Biological Sciences Research Council BB/L024128/1Biotechnology and Biological Sciences Research Council BB/L024225/1Biotechnology and Biological Sciences Research Council BB/N022440/1Biotechnology and Biological Sciences Research Council BB/R02216X/1Biotechnology and Biological Sciences Research Council BB/S01781X/1Biotechnology and Biological Sciences Research Council BB/T019557/1Biotechnology and Biological Sciences Research Council BB/T019670/1Biotechnology and Biological Sciences Research Council BB/V018779/1NHGRI NIH HHS U24 HG007822NIA NIH HHS U19 AG023122NIGMS NIH HHS R01 GM087221NIGMS NIH HHS R24 GM127667NLM NIH HHS R01 LM013115Wellcome TrustWellcome Trust 208391/Z/17/ZWellcome Trust 223745/Z/21/Z
6 · The paper itself

Abstract

The Human Proteome Organization (HUPO) Proteomics Standards Initiative (PSI) has been successfully developing guidelines, data formats, and controlled vocabularies (CVs) for the proteomics community and other fields supported by mass spectrometry since its inception 20 years ago. Here we describe the general operation of the PSI, including its leadership, working groups, yearly workshops, and the document process by which proposals are thoroughly and publicly reviewed in order to be ratified as PSI standards. We briefly describe the current state of the many existing PSI standards, some of which remain the same as when originally developed, some of which have undergone subsequent revisions, and some of which have become obsolete. Then the set of proposals currently being developed are described, with an open call to the community for participation in the forging of the next generation of standards. Finally, we describe some synergies and collaborations with other organizations and look to the future in how the PSI will continue to promote the open sharing of data and thus accelerate the progress of the field of proteomics.

Indexed as

ProteomeProteomicsDatabases, ProteinHumansMass SpectrometryReference StandardsVocabulary, ControlledProteomeHuman Proteome Organizationmass spectrometrymolecular interactionsproteomicsProteomics Standards Initiativestandards

Identifiers

PMID36626722
PMCPMC9903322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.