Evidence map›Paper›PMID 36626717›Full record

ArticleACS chemical biology2023

Activity of Fatty Acid Biosynthesis Initiating Ketosynthase FabH with Acetyl/Malonyl-oxa/aza(dethia)CoAs.

Trevor J Boram, Aaron B Benjamin, Amanda Silva de Sousa, Lee M Stunkard, Taylor A Stewart, Timothy J Adams, Nicholas A Craft, Kevin G Velázquez-Marrero, Jianheng Ling, Jaelen N Nice and 1 more

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Kinetic characterization of the C-terminal domain of Malonyl-CoA reductase.Biochimica et biophysica acta. Proteins and proteomics · 2024
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Trevor J BoramDepartment of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, Indiana 47907, United States.
Aaron B BenjaminDepartment of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, Indiana 47907, United States.
Amanda Silva de SousaDepartment of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, Indiana 47907, United States.
Lee M StunkardDepartment of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, Indiana 47907, United States.ORCID 0000-0003-4053-9134
Taylor A StewartDepartment of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, Indiana 47907, United States.
Timothy J AdamsDepartment of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, Indiana 47907, United States.
Nicholas A CraftDepartment of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, Indiana 47907, United States.
Kevin G Velázquez-MarreroDepartment of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, Indiana 47907, United States.
Jianheng LingDepartment of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-9821-2188
Jaelen N NiceDepartment of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, Indiana 47907, United States.
Jeremy R LohmanDepartment of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, Indiana 47907, United States.ORCID 0000-0001-8199-2344
Purdue University West Lafayette · US

Funding

Malonyl-thioester Isosteres to Determine Enzyme Structure-Function Relationships - Undergrad SupplementR01GM140290 · NIGMS · PURDUE UNIVERSITY · PI LOHMAN, JEREMY RAY · 2020 to 2023
$1.2M
NIGMS NIH HHS R01 GM140290
6 · The paper itself

Abstract

Fatty acid and polyketide biosynthetic enzymes exploit the reactivity of acyl- and malonyl-thioesters for catalysis. A prime example is FabH, which initiates fatty acid biosynthesis in many bacteria and plants. FabH performs an acyltransferase reaction with acetyl-CoA to generate an acetyl-

Indexed as

3-Oxoacyl-(Acyl-Carrier-Protein) SynthasePolyketidesAcetyl Coenzyme AAcyl Carrier ProteinAcyltransferasesFatty AcidsMalonyl Coenzyme A3-Oxoacyl-(Acyl-Carrier-Protein) SynthaseAcetyl Coenzyme AAcyl Carrier ProteinAcyltransferasesFatty AcidsMalonyl Coenzyme APolyketides

Identifiers

PMID36626717
PMCPMC10311946
OpenAlexW4315472025

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.