Evidence map›Paper›PMID 36626695›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2023

Racial and Ethnic Disparities in Opioid Access and Urine Drug Screening Among Older Patients With Poor-Prognosis Cancer Near the End of Life.

Andrea C Enzinger, Kaushik Ghosh, Nancy L Keating, David M Cutler, Cheryl R Clark, Narjust Florez, Mary Beth Landrum, Alexi A Wright

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
22.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Andrea C EnzingerDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0001-7502-8081
Kaushik GhoshNew England Bureau of Economic Research, Cambridge, MA.
Nancy L KeatingDepartment of Healthcare Policy, Harvard Medical School, Boston, MA.ORCID 0000-0002-8274-4681
David M CutlerNew England Bureau of Economic Research, Cambridge, MA.ORCID 0000-0002-4949-8917
Cheryl R ClarkDivision of General Internal Medicine and Primary Care, Department of Medicine, Brigham and Women's Hospital, Boston, MA.ORCID 0000-0001-6782-6382
Narjust FlorezDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0002-7814-1773
Mary Beth LandrumDepartment of Healthcare Policy, Harvard Medical School, Boston, MA.ORCID 0000-0001-5055-8473
Alexi A WrightDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0002-9776-7114
Dana-Farber Cancer Institute · USBrigham and Women's Hospital · USNational Bureau of Economic Research · USHarvard University · US

Funding

PA-20-072, Measuring the Clinical and Economic Outcomes Associated with Delivery Systems: "Are Health Systems Better at Responding to Pandemics?"U19HS024072 · AHRQ · NATIONAL BUREAU OF ECONOMIC RESEARCH · PI CUTLER, DAVID M · 2015 to 2021
$19.8M
AHRQ HHS U19 HS024072
6 · The paper itself

Abstract

purposeTo characterize racial and ethnic disparities and trends in opioid access and urine drug screening (UDS) among patients dying of cancer, and to explore potential mechanisms.

methodsAmong 318,549 non-Hispanic White (White), Black, and Hispanic Medicare decedents older than 65 years with poor-prognosis cancers, we examined 2007-2019 trends in opioid prescription fills and potency (morphine milligram equivalents [MMEs] per day [MMEDs]) near the end of life (EOL), defined as 30 days before death or hospice enrollment. We estimated the effects of race and ethnicity on opioid access, controlling for demographic and clinical factors. Models were further adjusted for socioeconomic factors including dual-eligibility status, community-level deprivation, and rurality. We similarly explored disparities in UDS.

resultsBetween 2007 and 2019, White, Black, and Hispanic decedents experienced steady declines in EOL opioid access and rapid expansion of UDS. Compared with White patients, Black and Hispanic patients were less likely to receive any opioid (Black, -4.3 percentage points, 95% CI, -4.8 to -3.6; Hispanic, -3.6 percentage points, 95% CI, -4.4 to -2.9) and long-acting opioids (Black, -3.1 percentage points, 95% CI, -3.6 to -2.8; Hispanic, -2.2 percentage points, 95% CI, -2.7 to -1.7). They also received lower daily doses (Black, -10.5 MMED, 95% CI, -12.8 to -8.2; Hispanic, -9.1 MMED, 95% CI, -12.1 to -6.1) and lower total doses (Black, -210 MMEs, 95% CI, -293 to -207; Hispanic, -179 MMEs, 95% CI, -217 to -142); Black patients were also more likely to undergo UDS (0.5 percentage points; 95% CI, 0.3 to 0.8). Disparities in EOL opioid access and UDS disproportionately affected Black men. Adjustment for socioeconomic factors did not attenuate the EOL opioid access disparities.

conclusionThere are substantial and persistent racial and ethnic inequities in opioid access among older patients dying of cancer, which are not mediated by socioeconomic variables.

Indexed as

Analgesics, OpioidNeoplasmsAgedDeathDrug Evaluation, PreclinicalEarly Detection of CancerHumansMaleMedicarePrognosisUnited StatesWhiteAnalgesics, Opioid

Identifiers

PMID36626695
PMCPMC10414726
OpenAlexW4315433779

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.