Evidence map›Paper›PMID 36626688›Full record

ArticleACS applied bio materials2023

Engineered Nonviral Protein Cages Modified for MR Imaging.

Megan A Kaster, Mikail D Levasseur, Thomas G W Edwardson, Michael A Caldwell, Daniela Hofmann, Giulia Licciardi, Giacomo Parigi, Claudio Luchinat, Donald Hilvert, Thomas J Meade

Abstract read
In one paragraph

Article in ACS applied bio materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Protein Cage Directed Assembly of Binary Nanoparticle Superlattices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Megan A KasterDepartments of Chemistry, Molecular Biosciences, Neurobiology and Radiology, Northwestern University, 2145 N. Sheridan Road, Evanston, Illinois60208, United States.ORCID 0000-0001-5550-4028
Mikail D LevasseurLaboratory of Organic Chemistry, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, Zürich8093, Switzerland.ORCID 0000-0003-4228-0875
Thomas G W EdwardsonLaboratory of Organic Chemistry, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, Zürich8093, Switzerland.ORCID 0000-0001-8661-8036
Michael A CaldwellDepartments of Chemistry, Molecular Biosciences, Neurobiology and Radiology, Northwestern University, 2145 N. Sheridan Road, Evanston, Illinois60208, United States.ORCID 0000-0002-8636-0706
Daniela HofmannLaboratory of Organic Chemistry, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, Zürich8093, Switzerland.
Giulia LicciardiMagnetic Resonance Center (CERM), University of Florence, via Luigi Sacconi 6, Sesto Fiorentino50019Italy.
Giacomo ParigiMagnetic Resonance Center (CERM), University of Florence, via Luigi Sacconi 6, Sesto Fiorentino50019Italy.ORCID 0000-0002-1989-4644
Claudio LuchinatMagnetic Resonance Center (CERM), University of Florence, via Luigi Sacconi 6, Sesto Fiorentino50019Italy.
Donald HilvertLaboratory of Organic Chemistry, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, Zürich8093, Switzerland.ORCID 0000-0002-3941-621X
Thomas J MeadeDepartments of Chemistry, Molecular Biosciences, Neurobiology and Radiology, Northwestern University, 2145 N. Sheridan Road, Evanston, Illinois60208, United States.ORCID 0000-0001-6202-1155

Funding

Real-Time Tracking of Gene Therapy by Bioactivated MR contrast ProbesR01NS115571 · NINDS · NORTHWESTERN UNIVERSITY · PI ESTEVES, MIGUEL S, GRAY-EDWARDS, HEATHER L · 2020 to 2024
$3.1M
Chemistry of Life Processes Predoctoral Training ProgramT32GM105538 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2013 to 2022
$2.7M
Bioresponsive MR probes for imaging pancreatic cancerF31CA235997 · NCI · NORTHWESTERN UNIVERSITY · PI KASTER, MEGAN · 2019 to 2022
$163k
NCI NIH HHS F31 CA235997NIGMS NIH HHS T32 GM105538NINDS NIH HHS R01 NS115571
6 · The paper itself

Abstract

Diagnostic medical imaging utilizes magnetic resonance (MR) to provide anatomical, functional, and molecular information in a single scan. Nanoparticles are often labeled with Gd(III) complexes to amplify the MR signal of contrast agents (CAs) with large payloads and high proton relaxation efficiencies (relaxivity,

Indexed as

NanoparticlesProtonsContrast MediaGadoliniumMagnetic Resonance ImagingContrast MediaGadoliniumProtonsgadoliniummagnetic resonance imagingmagnetismNMRDnonviral protein cages

Identifiers

PMID36626688
PMCPMC9945100

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.