Evidence map›Paper›PMID 36626557›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Molecular imaging of chemokine-like receptor 1 (CMKLR1) in experimental acute lung injury.

Philip Z Mannes, Clayton E Barnes, Jana Biermann, Joseph D Latoche, Kathryn E Day, Qin Zhu, Mohammadreza Tabary, Zeyu Xiong, Jessie R Nedrow, Benjamin Izar and 4 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Next-generation molecular imaging of cardiac fibrosis.The international journal of cardiovascular imaging · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. CD45-targeted PET enables the visualization of inflammatory conditions.American journal of nuclear medicine and molecular imaging · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. 2-deoxy-2-[Molecular imaging and biology · 2023
    Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Philip Z MannesDepartment of Radiology, University of Pittsburgh, Pittsburgh 15213, PA.ORCID 0000-0003-3080-8863
Clayton E BarnesDepartment of Radiology, University of Pittsburgh, Pittsburgh 15213, PA.ORCID 0000-0001-8943-7564
Jana BiermannDepartment of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York 10032, NY.ORCID 0000-0002-8907-4633
Joseph D LatocheDepartment of Medicine, University of Pittsburgh, Pittsburgh 15213, PA.
Kathryn E DayDepartment of Medicine, University of Pittsburgh, Pittsburgh 15213, PA.
Qin ZhuDepartment of Radiology, University of Pittsburgh, Pittsburgh 15213, PA.
Mohammadreza TabaryDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh 15213, PA.
Zeyu XiongDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh 15213, PA.
Jessie R NedrowDepartment of Radiology, University of Pittsburgh, Pittsburgh 15213, PA.
Benjamin IzarDepartment of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York 10032, NY.
Carolyn J AndersonDepartment of Chemistry, University of Missouri, Columbia 65211, MO.
Flordeliza S VillanuevaDepartment of Medicine, University of Pittsburgh, Pittsburgh 15213, PA.
Janet S LeeDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh 15213, PA.
Sina TavakoliDepartment of Radiology, University of Pittsburgh, Pittsburgh 15213, PA.ORCID 0000-0003-0574-3914
University of Pittsburgh · USColumbia University Irving Medical Center · USUniversity of Missouri · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
Regulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCVERRY, BRYAN J · 2014 to 2023
$21.3M
Mechanisms of host protection against pathogen-secreted proteases in acute lung injuryR01HL136143 · NHLBI · WASHINGTON UNIVERSITY · PI LEE, JANET SOJUNG · 2017 to 2024
$4.4M
Mechanisms of liver metastasis and associated resistance to immunotherapyR37CA258829 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Benjamin Izar · 2021 to 2026
$2.6M
The role of ACOD1 in immunomodulation in intrapulmonary Klebsiella pneumoniae infectionR01HL142084 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, KONG · 2018 to 2021
$2.4M
Dissecting mechanisms of immunotherapy resistance in melanoma patientsK08CA222663 · NCI · DANA-FARBER CANCER INST · PI IZAR, BENJAMIN · 2017 to 2021
$827k
A Molecular Imaging Approach to Immuno-Metabolic Characterization of Vessel Wall MacrophagesK08HL144911 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TAVAKOLI, SINA · 2019 to 2023
$813k
Novel Protease-Activatable Tracers for Targeted Imaging of Chemerin Receptor in InflammationR21EB027871 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TAVAKOLI, SINA · 2020 to 2022
$626k
Patient-Oriented Research in Acute Lung Injury and Host Defense in the ICUK24HL143285 · NHLBI · WASHINGTON UNIVERSITY · PI LEE, JANET SOJUNG · 2019 to 2023
$579k
Dissecting drug resistance in serial uveal melanoma biopsies using integrated, multi-modal single-cell profiling and novel machine learning tools.R21CA263381 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IZAR, BENJAMIN · 2021 to 2022
$412k
Request for an Olympus VS200 slide scannerS10MH126905 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FISH, KENNETH N, WATKINS, SIMON C · 2021 to 2021
$370k
Molecular Imaging of the ChemR23-Chemerin Axis in Acute Lung InjuryF30HL158038 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MANNES, PHILIP ZACHARY · 2021 to 2024
$209k
NCI NIH HHS K08 CA222663NCI NIH HHS P30 CA047904NCI NIH HHS R21 CA263381NCI NIH HHS R37 CA258829NHLBI NIH HHS F30 HL158038NHLBI NIH HHS K08 HL144911NHLBI NIH HHS K24 HL143285NHLBI NIH HHS P01 HL114453NHLBI NIH HHS R01 HL136143NHLBI NIH HHS R01 HL142084NIBIB NIH HHS R21 EB027871NIMH NIH HHS S10 MH126905
6 · The paper itself

Abstract

The lack of techniques for noninvasive imaging of inflammation has challenged precision medicine management of acute respiratory distress syndrome (ARDS). Here, we determined the potential of positron emission tomography (PET) of chemokine-like receptor-1 (CMKLR1) to monitor lung inflammation in a murine model of lipopolysaccharide-induced injury. Lung uptake of a CMKLR1-targeting radiotracer, [

Indexed as

Acute Lung InjuryCOVID-19Respiratory Distress SyndromeAnimalsChemokinesHumansLipopolysaccharidesLungMiceMolecular ImagingReceptors, ChemokineChemokinesCMKLR1 protein, humanCMKLR1 protein, mouseLipopolysaccharidesReceptors, Chemokineacute lung injuryCMKLR1inflammationmacrophagepositron emission tomography

Identifiers

PMID36626557
PMCPMC9934297
OpenAlexW4315436192

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.