Evidence map›Paper›PMID 36626551›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

CITED2 is a conserved regulator of the uterine-placental interface.

Marija Kuna, Pramod Dhakal, Khursheed Iqbal, Esteban M Dominguez, Lindsey N Kent, Masanaga Muto, Ayelen Moreno-Irusta, Keisuke Kozai, Kaela M Varberg, Hiroaki Okae and 3 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Directed differentiation of bovine trophoblast stem cells: A useful in vitro model for placenta development.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Trophoblast differentiation in the bovine placenta.The Journal of reproduction and development · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. NOTUM-mediated WNT silencing drives extravillous trophoblast cell lineage development.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Cited2 is a key regulator of placental development and plasticity.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Single-cell insights into epithelial morphogenesis in the neonatal mouse uterus.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Marija KunaDepartment of Pathology and Laboratory Medicine, Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, KS 66160.ORCID 0000-0002-5367-731X
Pramod DhakalDepartment of Pathology and Laboratory Medicine, Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, KS 66160.
Khursheed IqbalDepartment of Pathology and Laboratory Medicine, Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, KS 66160.ORCID 0000-0002-6742-4591
Esteban M DominguezDepartment of Pathology and Laboratory Medicine, Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, KS 66160.
Lindsey N KentDepartment of Pathology and Laboratory Medicine, Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, KS 66160.
Masanaga MutoDepartment of Pathology and Laboratory Medicine, Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, KS 66160.
Ayelen Moreno-IrustaDepartment of Pathology and Laboratory Medicine, Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, KS 66160.
Keisuke KozaiDepartment of Pathology and Laboratory Medicine, Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, KS 66160.
Kaela M VarbergDepartment of Pathology and Laboratory Medicine, Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, KS 66160.ORCID 0000-0001-9672-4158
Hiroaki OkaeDepartment of Informative Genetics, Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Takahiro ArimaDepartment of Informative Genetics, Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.ORCID 0000-0001-8094-5167
Henry M SucovDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425.ORCID 0000-0002-3792-3795
Michael J SoaresDepartment of Pathology and Laboratory Medicine, Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, KS 66160.ORCID 0000-0001-7158-1592
University of Kansas Medical Center · USTohoku University · JPMedical University of South Carolina · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI John A Stanford · 2012 to 2026
$63.0M
TROPHOBLAST DIFFERENTIATIONR01HD020676 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MICHAEL J SOARES · 1986 to 2026
$10.1M
Stem Cells and Epigenetics of Trophoblast Lineage DevelopmentP01HD079363 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI PAUL, SOUMEN · 2014 to 2018
$5.7M
Anti-Coagulation Factors and PlacentationR01HD099638 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SOARES, MICHAEL J · 2019 to 2023
$2.5M
Trophoblast-Guided Uterine Transformation in the Establishment of PregnancyR01HD105734 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MICHAEL J SOARES · 2022 to 2026
$2.2M
Trophoblast-Uterine Cell Dynamics at the Maternal-Fetal InterfaceR21HD104033 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SOARES, MICHAEL J, TUTEJA, GEETU · 2020 to 2021
$424k
Supplement (Covid) to Regulation of endovascular trophoblast cell development and uterine spiral artery remodelingF32HD096809 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI VARBERG, KAELA MARGARET · 2018 to 2021
$232k
Regulation of Invasive Trophoblast Cell Lineage DevelopmentK99HD107262 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI VARBERG, KAELA MARGARET · 2022 to 2023
$142k
NICHD NIH HHS F32 HD096809NICHD NIH HHS K99 HD107262NICHD NIH HHS P01 HD079363NICHD NIH HHS R01 HD020676NICHD NIH HHS R01 HD099638NICHD NIH HHS R01 HD105734NICHD NIH HHS R21 HD104033NIGMS NIH HHS P20 GM103418
6 · The paper itself

Abstract

Establishment of the hemochorial uterine-placental interface requires exodus of trophoblast cells from the placenta and their transformative actions on the uterus, which represent processes critical for a successful pregnancy, but are poorly understood. We examined the involvement of CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) in rat and human trophoblast cell development. The rat and human exhibit deep hemochorial placentation. CITED2 was distinctively expressed in the junctional zone (JZ) and invasive trophoblast cells of the rat. Homozygous

Indexed as

PlacentaPlacentationRepressor ProteinsTrans-ActivatorsAnimalsFemaleHumansPregnancyRatsTranscription FactorsTrophoblastsUterusCITED2 protein, humanCITED2 protein, ratRepressor ProteinsTrans-ActivatorsTranscription FactorsCITED2placentapregnancystem cellstrophoblast

Identifiers

PMID36626551
PMCPMC9934066
OpenAlexW4315436987

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.