Evidence map›Paper›PMID 36626529›Full record

SynthesisMedicine2022

An overview of third, fourth and sixth cranial nerve palsies in the setting of COVID-19: A case report and systematic review.

Mostafa Meshref, Nour Shaheen, Sarya Swed, Mohamed Ibrahim, Mostafa Reda Mostafa, Mohamed Osman Algazar, Monica Dobs, Sarah Ibrahim Elsayed, Yara Amro, Ahmed Afsa and 1 more

Open access · goldAbstract readCase ReportsSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 4 countries.

Mostafa MeshrefAl-Azhar University, Cairo, Egypt.
Nour ShaheenAlexandria University, Alexandria Faculty of Medicine, Alexandria, Egypt.ORCID 0000-0001-8663-4044
Sarya SwedAleppo University, Faculty of Medicine, Aleppo, Syria.ORCID 0000-0002-9983-2020
Mohamed IbrahimEssex Partnership University NHS Foundation Trust, Wickford, UK.
Mostafa Reda MostafaRochester Regional Health/Unity Hospital, Rochester, USA.
Mohamed Osman AlgazarResident of Neurology, Alharam Hospital, Giza, Egypt.
Monica DobsUniversity of Florida College of Medicine Jacksonville, Jacksonville, USA.
Sarah Ibrahim ElsayedFaculty of Medicine, Zagazig University, Zagazig, Egypt.
Yara AmroPharmacist Ministry of Health, Cairo, Egypt.
Ahmed AfsaEmergency Department, Pilgrim Hospital, United Lincolnshire NHS Trust, Boston, UK.
Mostafa Ebraheem MorraGastroenterology Department, Pilgrim Hospital, United Lincolnshire NHS Trust, Boston, UK.
Pilgrim Hospital · GBAl-Azhar University · EGAlexandria University · EGFlorida College · USSouth Essex Partnership University Foundation NHS Trust · GBUnity Health System · USUniversity of Aleppo · SYZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCovid-19 has serious sequelae that may be poorly understood, underreported, and, as a result, not diagnosed promptly, such as variations in clinical manifestations of hyperinflammation among people infected with SARS-CoV-2. ophthalmoplegia can be one of these manifestations.

methodsWe are reporting a 55-year-old male patient with unilateral diplopia considering it as a case of multisystem inflammatory syndrome in adults. We also reviewed the literature systematically for the previously reported studies/cases with third, fourth and sixth cranial nerve palsies due to or after Covid-19.

resultsThe literature search yielded 17 studies reporting 29 patients. 71.4% of the patients were males with a mean age of 42.23 years. Ophthalmological symptoms took 9.7 days to appear after the respiratory involvement. All patients had diplopia as part of their visual symptoms. 41.4% of the patients had unilateral sixth nerve palsy, 24% had bilateral sixth nerve involvement, 17% had fourth nerve involvement, and 27.6% had third nerve involvement.

conclusionOphthalmoplegia is considered presenting symptom of Covid-19. Further research is needed to detect all neuro-ophthalmological manifestations of Covid-19.

Indexed as

Abducens Nerve DiseasesCOVID-19Cranial Nerve DiseasesOculomotor Nerve DiseasesOphthalmoplegiaAdultDiplopiaFemaleHumansMaleMiddle AgedSARS-CoV-2

Identifiers

PMID36626529
PMCPMC9750665
OpenAlexW4315436939

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.