Evidence map›Paper›PMID 36626503›Full record

Observational studyMedicine2022

Role of serum cystatin C in the prediction of acute kidney injury following pediatric cardiac surgeries: A single center experience.

Marwa Zakaria, Tamer Hassan, Ali Refaat, Manar Fathy, Mustafa I A Hashem, Naglaa Khalifa, Ahmed A Ali, Ahmed Elhewala, Ahmed Ramadan, Alaa Nafea

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Marwa ZakariaPediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Tamer HassanPediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ali RefaatCardiothoracic Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Manar FathyPediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Mustafa I A HashemPediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Naglaa KhalifaClinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ahmed A AliPediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ahmed ElhewalaPediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ahmed RamadanPediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Alaa NafeaPediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Zagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intense contemporary research is directed towards validating novel biomarkers to predict acute kidney injury (AKI) in children undergoing cardiothoracic surgeries. We aimed to evaluate the role of cystatin C in early prediction of AKI following cardiac surgery in children with congenital heart disease. Prospective observational cohort study was conducted on 40 children with congenital heart disease undergoing cardiac surgery. 40 healthy children with matched age and sex were enrolled as a control group. Children were subjected to physical examination, routine blood tests, echocardiography, and measurement of plasma cystatin C level on different occasions. The median age of the patients was 3.65 years, a range from 1 to 5 years with no significant difference regarding the age and sex of cases and control groups. The mean serum cystatin C level in patients was 0.75 ± 0.15, 1.35 ± 0.34 and 1.21 ± 0.38 mg/dL (preoperative, at 6 h and at 24 h postoperative, respectively) with statistically significant difference P < .05. 30% of the patients developed postoperative AKI with significantly higher serum cystatin C at 6 hours postoperative >1.33 mg/dL compared to preoperative level p P < .05. Serum cystatin C level was positively correlated with cardiac bypass time, ischemic time and length of hospital stay at 6 hours postoperative. Serum cystatin C is a sensitive marker for early detection of AKI following cardiac surgery in children with congenital heart disease and it was positively correlated with cardiac bypass time, ischemic time and length of hospital stay.

Indexed as

Acute Kidney InjuryCardiac Surgical ProceduresHeart Defects, CongenitalBiomarkersChild, PreschoolCreatinineCystatin CHumansInfantPredictive Value of TestsProspective StudiesBiomarkersCreatinineCystatin C

Identifiers

PMID36626503
PMCPMC9750614
OpenAlexW4315435759

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.