Evidence map›Paper›PMID 36626488›Full record

ArticleMedicine2022

Identification and verification of microRNA signature and key genes in the development of osteosarcoma with lung metastasis.

Fanjian Meng, Lulu Wang, Guangyu Gao, Jinpeng Chen, Xinghua Wang, Gaochen Wu, Yiqi Miu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Fanjian MengDepartment of Orthopedics, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, P.R. China.
Lulu WangDepartment of Orthopedics, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, P.R. China.
Guangyu GaoDepartment of Oocology, the Second Affiliated Hospital of Soochow University, Suzhou, P.R. China.
Jinpeng ChenDepartment of Orthopedics, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, P.R. China.
Xinghua WangDepartment of Orthopedics, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, P.R. China.
Gaochen WuDepartment of Orthopedics, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, P.R. China.
Yiqi MiuDepartment of Orthopedics, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, P.R. China.ORCID 0000-0003-4718-9050
Suzhou Traditional Chinese Medicine Hospital · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsteosarcoma (OS) is a heterogeneous malignant spindle cell tumor in children under the age of 20. This study aims to research the association between Solute Carrier Family 7 Member 8 (SLC7A8) as well as related genes and OS.

methodOS and normal samples (GSE38698 and GSE85537) were downloaded from Gene Expression Omnibus dataset. The bioinformatics analysis was performed to distinguish 2 differentially expressed genes, prognostic candidate genes and functional enrichment pathway. Immunohistochemistry and quantitative real-time PCR were utilized for further study.

resultsThere were 5 DEMs and 10 differentially expressed genes in cancer tissues compared to normal tissues. According to the km-plot software, ARHGEF3, BSN, PQLC3, and SLC7A8 were significantly related to the overall survival of patients with OS. Furthermore, Multivariate analysis included that SLC7A8 was independent risk factors for OS patients. Furthermore, immunohistochemistry and quantitative real-time PCR outcomes indicated that the expression level of SLC7A8 and hsa-miR-506 was differentially expressed in lung metastasis OS tissues and non-metastasis tissues.

conclusionThe prognostic model based on the miRNA-mRNA network could provide predictive significance for prognosis of OS patients, which would be worthy of clinical application. Our results concluded that SLC7A8 may play a key role in the development of OS.

Indexed as

Bone NeoplasmsLung NeoplasmsMicroRNAsOsteosarcomaAmino Acid Transport System y+Fusion Regulatory Protein 1, Light ChainsHumansRNA, MessengerAmino Acid Transport System y+Fusion Regulatory Protein 1, Light ChainsMicroRNAsMIRN506 microRNA, humanRNA, MessengerSLC7A8 protein, human

Identifiers

PMID36626488
PMCPMC9750666
OpenAlexW4315436967

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.