ArticleMedicine2022
Association of urinary caffeine and caffeine metabolites with bone mineral density in children and adolescents.
Article in Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Principal Components Analysis of Spot Urine Caffeine and Caffeine Metabolites Identifies Promising Exposure Biomarkers of Caffeine and Theobromine Intake in a Cross-Sectional Survey of the United States Population (National Health and Nutrition Examination Survey 2009-2014).Current developments in nutrition · 2025Article
- Correlation betweenArchives of medical science : AMS · 2025Article
- Association between nineteen dietary fatty acids and hearing thresholds: findings from a nationwide survey.Lipids in health and disease · 2023Article
- Pregnancy and lactation-associated osteoporosis with pyogenic spondylitis: A case report.World journal of clinical cases · 2023Article
- Associations between weight-adjusted waist index and fractures: a population-based study.Journal of orthopaedic surgery and research · 2023Article
- BMI, socioeconomic status, and bone mineral density in U.S. adults: Mediation analysis in the NHANES.Frontiers in nutrition · 2023Article
- Composite Dietary Antioxidant Index Is Negatively Associated with Hyperuricemia in US Adults: An Analysis of NHANES 2007-2018.International journal of endocrinology · 2023Article
- Association of family income to poverty ratio and vibration-controlled transient elastography quantified degree of hepatic steatosis in U.S. adolescents.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In epidemiological research, the link between coffee consumption and bone mineral density (BMD) is still debated. Moreover, there hasn't been any research on the relationship between urine caffeine and caffeine metabolites and BMD. This study aimed to investigate if there was a connection between urine caffeine and its metabolites and BMD in people between the ages of 8 and 19. Using data from the National Health and Nutrition Examination Survey 2009 to 2014, multivariate logistic regression models were utilized to investigate the association between urinary caffeine and caffeine metabolites and total BMD. Fitted smoothing curves and generalized additive models were also used. A total of 1235 adolescents were included in this analysis, after controlling for various variables, we found that the association between urinary theophylline and total BMD was negative, whereas the association between urinary paraxanthine, theobromine and caffeine and total BMD was positive. In our study, an inverted U-shaped association between urinary paraxanthine and urinary caffeine was found with BMD in women. In this cross-sectional study, the correlation between urinary caffeine and its metabolites and total BMD differed by sex and race. More studies are needed to confirm the results of this study and to investigate the underlying causes.
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Registered trials
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