ArticleJCI insight2023
Low nephron endowment increases susceptibility to renal stress and chronic kidney disease.
Article in JCI insight, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Trial
- Fetal growth restriction leads to prolonged nephrogenesis and gene dysregulation in the adult kidney.Life science alliance · 2026Article
- Developmental origins of hypertension and renal injury: epigenetic memory in renal stem and progenitor cells.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Preterm birth disrupts nephron progenitor cell dynamics predisposing to renal disease.iScience · 2026Article
- Predictors of Acute Kidney Injury and In-Hospital Mortality in Patients With RT-PCR Confirmed Lassa Fever in Southwest Nigeria.Open forum infectious diseases · 2026Article
- Capturing systemic disease burden in MASLD: Toward integrated liver-kidney-cardiovascular economic models: Reply to correspondence on "Evaluating treatment response thresholds for cost-effective treatment in metabolic dysfunction-associated steatotic liver disease".Clinical and molecular hepatology · 2026Article
- Megalin (LRP2), prenatal betamethasone, and injury susceptibility in the developing kidney.bioRxiv : the preprint server for biology · 2026Article
- A Model to Define Reference Ultrasound Parameters for Early Assessment of Nephron Endowment in Extremely Low Birth Weight Preterm Infants.Children (Basel, Switzerland) · 2026Article
- Protecting Kidney Health in the First 1000 Days: The Pediatrician's Role in Safeguarding the Weakest.Diseases (Basel, Switzerland) · 2026Review
- Kidney Volume as a Predictor and Modifier of Acute Kidney Injury with Renin-Angiotensin System Inhibitors.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- The Link Between Preterm Birth and Long-Term Renal Consequences: Current Knowledge and Emerging Therapeutic Targets.Biomedicines · 2026Review
- Integration of spatial and single-nucleus transcriptomics to map gene expression in the developing mouse kidney.Development (Cambridge, England) · 2025Article
- Downregulated miR-199a-3p in Preeclamptic Placenta-derived Exosomes from Cord Blood Hinders VEGF-induced Fetal Glomerular Dysplasia Through Inhibiting Akt1(S473) Phosphorylation via Targeting PHLPP2.Stem cell reviews and reports · 2025Article
- Review
- Renal-clearable and mitochondria-targeted metal-engineered carbon dot nanozymes for regulating mitochondrial oxidative stress in acute kidney injury.Materials today. Bio · 2025Article
- The challenges for developing prognostic prediction models for acute kidney injury in hospitalized children: A systematic review.Pediatric investigation · 2025Review
- The border between progenitor cell recruitment and nephron shaping in the fetal human kidney during late gestation: a basic but understudied region.Frontiers in nephrology · 2025Article
- Radial Expansion of the Nephrogenic Zone in the Fetal Human Kidney During Advanced Pregnancy: A Microanatomical Look at a Little Noticed Process.International journal of nephrology · 2025Article
- Article
- Acute Kidney Injury in Neonatal Intensive Care Unit: Epidemiology, Diagnosis and Risk Factors.Journal of clinical medicine · 2024Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Preterm birth results in low nephron endowment and increased risk of acute kidney injury (AKI) and chronic kidney disease (CKD). To understand the pathogenesis of AKI and CKD in preterm humans, we generated potentially novel mouse models with a 30%-70% reduction in nephron number by inhibiting or deleting Ret tyrosine kinase in the developing ureteric bud. These mice developed glomerular and tubular hypertrophy, followed by the transition to CKD, recapitulating the renal pathological changes seen in humans born preterm. We injected neonatal mice with gentamicin, a ubiquitous nephrotoxic exposure in preterm infants, and detected more severe proximal tubular injury in mice with low nephron number compared with controls with normal nephron number. Mice with low nephron number had reduced proliferative repair with more rapid development of CKD. Furthermore, mice had more profound inflammation with highly elevated levels of MCP-1 and CXCL10, produced in part by damaged proximal tubules. Our study directly links low nephron endowment with postnatal renal hypertrophy, which in this model is maladaptive and results in CKD. Underdeveloped kidneys are more susceptible to gentamicin-induced AKI, suggesting that AKI in the setting of low nephron number is more severe and further increases the risk of CKD in this vulnerable population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.