Evidence map›Paper›PMID 36626187›Full record

ArticleThe Journal of infectious diseases2023

Pfizer-BioNTech Coronavirus Disease 2019 Vaccine Effectiveness Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Long-term Care Facility Staff With and Without Prior Infection in New York City, January-June 2021.

Kathryn Peebles, Robert J Arciuolo, Anthony S Romano, Jessica Sell, Sharon K Greene, Sungwoo Lim, Candace Mulready-Ward, Alexandra Ternier, Brittan Badenhop, Kathleen Blaney and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kathryn PeeblesEpidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Robert J ArciuoloDivision of Disease Control, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Anthony S RomanoDivision of Disease Control, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Jessica SellDivision of Disease Control, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Sharon K GreeneDivision of Disease Control, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Sungwoo LimDivision of Epidemiology, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Candace Mulready-WardDivision of Family and Child Health, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Alexandra TernierDivision of Disease Control, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Brittan BadenhopDivision of Disease Control, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Kathleen BlaneyDivision of Disease Control, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Joseph E RealDivision of Disease Control, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Magdalene SpencerDivision of Disease Control, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Tristan D McPhersonDivision of Disease Control, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Shama Desai AhujaDivision of Disease Control, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Jeanne Sullivan MeissnerDivision of Disease Control, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Jane R ZuckerDivision of Disease Control, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Jennifer B RosenDivision of Disease Control, New York City Department of Health and Mental Hygiene, Queens, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence is accumulating of coronavirus disease 2019 (COVID-19) vaccine effectiveness among persons with prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

methodsWe evaluated the effect against incident SARS-CoV-2 infection of (1) prior infection without vaccination, (2) vaccination (2 doses of Pfizer-BioNTech COVID-19 vaccine) without prior infection, and (3) vaccination after prior infection, all compared with unvaccinated persons without prior infection. We included long-term care facility staff in New York City aged <65 years with weekly SARS-CoV-2 testing from 21 January to 5 June 2021. Test results were obtained from state-mandated laboratory reporting. Vaccination status was obtained from the Citywide Immunization Registry. Cox proportional hazards models adjusted for confounding with inverse probability of treatment weights.

resultsCompared with unvaccinated persons without prior infection, incident SARS-CoV-2 infection risk was lower in all groups: 54.6% (95% confidence interval, 38.0%-66.8%) lower among unvaccinated, previously infected persons; 80.0% (67.6%-87.7%) lower among fully vaccinated persons without prior infection; and 82.4% (70.8%-89.3%) lower among persons fully vaccinated after prior infection.

conclusionsTwo doses of Pfizer-BioNTech COVID-19 vaccine reduced SARS-CoV-2 infection risk by ≥80% and, for those with prior infection, increased protection from prior infection alone. These findings support recommendations that all eligible persons, regardless of prior infection, be vaccinated against COVID-19.

Indexed as

COVID-19COVID-19 VaccinesBNT162 VaccineCOVID-19 TestingHumansLong-Term CareNew York CityNursing HomesSARS-CoV-2BNT162 VaccineCOVID-19 VaccinesCOVID-19 vaccine effectivenesslong-term care facilitiesSARS-CoV-2 reinfection

Identifiers

PMID36626187
PMCPMC9927076

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.