Evidence map›Paper›PMID 36626101›Full record

SynthesisEuropean journal of epidemiology2023

Physical activity and risk of chronic kidney disease: systematic review and meta-analysis of 12 cohort studies involving 1,281,727 participants.

Samuel Seidu, Mohammad Abdool, Abdullah Almaqhawi, Thomas J Wilkinson, Setor K Kunutsor, Kamlesh Khunti, Tom Yates

Open access · hybridFull text readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Lifestyle and Environment Aspects Challenging Kidney Health.Kidney & blood pressure research · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Physical activity and cardiorenal health-from associations to interventional studies.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  13. Elevated Pulse Pressure and Risk of Chronic Kidney Disease by Hypertension Status: A Longitudinal Study in Japanese Adults.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Observational
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Samuel SeiduDiabetes Research Centre, University of Leicester, Leicester, UK. sis11@leicester.ac.uk.ORCID http://orcid.org/0000-0002-8335-7018
Mohammad AbdoolHockley Farm Medical Practice, Leicester, UK.
Abdullah AlmaqhawiDepartment of Family and Community Medicine, College of Medicine, King Faisal University, Dammam, Saudi Arabia.
Thomas J WilkinsonDiabetes Research Centre, University of Leicester, Leicester, UK.
Setor K KunutsorNational Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust, University of Bristol, Bristol, UK.
Kamlesh KhuntiDiabetes Research Centre, University of Leicester, Leicester, UK.
Tom YatesDiabetes Research Centre, University of Leicester, Leicester, UK.
University of Leicester · GBKing Faisal University · SAUniversity Hospitals Bristol NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of regular physical activity in preventing vascular and non-vascular disease is well established. Chronic kidney disease (CKD) is a major cause of global morbidity and mortality and largely preventable, but it is uncertain if regular physical activity can reduce the risk of CKD. Using a systematic review and meta-analysis of published observational cohort studies in the general population, we sought to assess the association between physical activity and CKD risk. Relevant studies with at least one-year of follow-up were sought from inception until 02 May 2022 in MEDLINE, Embase, Web of Science, and manual search of relevant articles. Relative risks (RRs) with 95% confidence intervals (CIs) for the maximum versus the minimal amount of physical activity groups were pooled using random effects meta-analysis. The quality of the evidence was evaluated using the GRADE tool. A total of 12 observational cohort studies comprising 1,281,727 participants and 66,217 CKD events were eligible for the analysis. The pooled multivariable-adjusted RR (95% CI) of CKD comparing the most versus the least physically active groups was 0.91 (0.85-0.97). The association was consistent across several study level subgroups. Exclusion of any single study at a time from the meta-analysis did not change the direction or significance of the association. There was no evidence of small study effects among contributing studies. The GRADE quality of the evidence was low. In the general population, individuals who are most physically active have a lowered risk of CKD compared to those who are not or least physically active. CRD42022327640.

Indexed as

Renal Insufficiency, ChronicCohort StudiesExerciseHumansChronic kidney diseaseCohort studyMeta-analysisPhysical activityRisk factorSystematic review

Identifiers

PMID36626101
PMCPMC10033580
OpenAlexW4313898660

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read20
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.