Evidence map›Paper›PMID 36626067›Full record

ArticleMolecular biology reports2023

Association between the ELAVL1 gene single nucleotide polymorphisms and the Genetic Susceptibility to cervical cancer by high resolution melting in a Tunisian population.

Najet Boudhiba, Sana Sfar, Ahlem Helaoui, Ines Bouanene, Marcin Hołysz, EwaIwańczyk Skalska, Haifa Bouchahda, Paweł P Jagodziński, Abderraouf Kenani

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Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Role of the RNA-binding protein family in gynecologic cancers.American journal of cancer research · 2023
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4 · The record

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5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Najet BoudhibaResearch Laboratory "Environment, Inflammation, Signalling and Pathologies" (LR18ES40), Faculty of Medicine of Monastir, University of Monastir, 5000, Monastir, Tunisia. najetboudhiba@gmail.com.ORCID http://orcid.org/0000-0002-2369-5031
Sana SfarResearch Laboratory "Environment, Inflammation, Signalling and Pathologies" (LR18ES40), Faculty of Medicine of Monastir, University of Monastir, 5000, Monastir, Tunisia.
Ahlem HelaouiResearch Laboratory "Environment, Inflammation, Signalling and Pathologies" (LR18ES40), Faculty of Medicine of Monastir, University of Monastir, 5000, Monastir, Tunisia.
Ines BouaneneDepartment of Community Medicine Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia.
Marcin HołyszDepartment of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 6 S´wie˛cickiego St, 60-781, Poznan, Poland.
EwaIwańczyk SkalskaDepartment of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 6 S´wie˛cickiego St, 60-781, Poznan, Poland.
Haifa BouchahdaDepartment of Gynaecology Obstetric, University of Monastir, Tahar Sfar University Hospital, 5111, Mahdia, Tunisia.
Paweł P JagodzińskiDepartment of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 6 S´wie˛cickiego St, 60-781, Poznan, Poland.
Abderraouf KenaniResearch Laboratory "Environment, Inflammation, Signalling and Pathologies" (LR18ES40), Faculty of Medicine of Monastir, University of Monastir, 5000, Monastir, Tunisia.
University of Monastir · TNPoznan University of Medical Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman papillomavirus is the major cause of cervical cancer, but only few cases develop into cancer. Nevertheless, HuR (ELAVL1) gene has been implicated in the oncogenesis of certain cancers. The correlation between ELAVL1 gene and the risk of cervical cancer remains unclear. Therefore, this study investigated the effect of ELAVL1 gene polymorphisms (SNPs) in cervical cancer development in Tunisian women.

methodELAVL1 gene SNPs: ELAVL1 rs12983784 T > C, ELAVL1 rs14394 T > C, ELAVL1 rs74369359 G > T, ELAVL1 rs35986520 G > A, ELAVL1 rs10402477 C > T, ELAVL1 rs12985234 A > G and ELAVL1 rs2042920 T > G, were genotyped by High resolution melting (HRM). SNPStats software was used to perform linkage disequilibrium (LD) and haplotype analysis.

resultsComparing the cervical cancer patients with healthy control participants, the SNPs rs12983784 (P = 0.032), rs74369359 (p = < 10

conclusionOur results indicated that genetic variants in the ELAVL1 gene might be associated with susceptibility to cervical cancer in the Tunisian population.

Indexed as

Genetic Predisposition to DiseaseUterine Cervical NeoplasmsCase-Control StudiesELAV-Like Protein 1FemaleGene FrequencyGenotypeHaplotypesHumansLinkage DisequilibriumPolymorphism, Single NucleotideELAVL1 protein, humanELAV-Like Protein 1Cervical cancerHRMHuRPolymorphismRNA-binding protein

Identifiers

PMID36626067
OpenAlexW4313948723

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.