ArticlePediatric nephrology (Berlin, Germany)2023
CARPEDIEM® for continuous kidney replacement therapy in neonates and small infants: a French multicenter retrospective study.
Article in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Risk factors for acute kidney injury in very-low birth weight newborns: a systematic review with meta-analysis.European journal of pediatrics · 2024Pooled it
- Peritoneal dialysis catheter complications in neonates with kidney failure.Pediatric nephrology (Berlin, Germany) · 2026Article
- Continuous kidney replacement therapy in low birth weight and premature neonates-are we entering a new era?Pediatric nephrology (Berlin, Germany) · 2026Article
- CAKUT calculator: a clinical risk prediction tool for in-hospital mortality in neonates with congenital anomalies of the kidney and urinary tract admitted to level IV NICUs.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Continuous kidney replacement therapy with CARPEDIEMPediatric nephrology (Berlin, Germany) · 2026Article
- Early continuous renal replacement therapy for acute kidney injury in a very low birth weight infant: a case report and literature review.Frontiers in medicine · 2026Article
- Renal replacement therapy in intensive care unit: a narrative review.Annals of intensive care · 2026Review
- Continuous renal replacement therapy in neonates with multiple organ dysfunction syndrome: clinical utilization effects and outcomes.Italian journal of pediatrics · 2025Article
- Evaluation of anticoagulant methods in newborns undergoing continuous renal replacement therapy: what is the optimum method?European journal of pediatrics · 2025Article
- AEIOU strategy for continuous renal replacement therapy in infants <10 kg: a practical and educational framework.Frontiers in pediatrics · 2025Review
- Predicting the Impact of Polysulfone Dialyzers and Binder Dialysate Flow Rate on Bilirubin Removal.Bioengineering (Basel, Switzerland) · 2024Article
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Authors and funding
14 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Cardio-Renal Pediatric Dialysis Emergency Machine (CA.R.P.E.D.I.E.M.®) device is a continuous kidney replacement therapy (CKRT) equipment dedicated to neonates and small infants. This study aimed to assess the effectiveness, feasibility, outcomes, and technical considerations relating to CARPEDIEM® use.
methodsThis retrospective multicenter study included 19 newborns and six infants receiving CARPEDIEM® in five French pediatric and neonatal intensive care units. Laboratory parameters were collected at the initiation and end of the first CARPEDIEM® session. Results are presented as median [IQR] (range).
resultsAt initiation, age was 4 days [2-13] (1-1134) with a body weight of 3.3 kg [2.5-4] (1.3-11.1). Overall, 131 sessions and 2125 h of treatment were performed. Treatment duration per patient was 42 h [24-91] (8-557). Continuous veno-venous hemofiltration (CVVH) was performed in 20 children. Blood flow rate was 8 mL/kg/min [6-9] (3-16). The effluent flow rate for CVVH was 74 mL/kg/h [43-99] (28-125) and net ultrafiltration (UF) 6 mL/kg/h [2-8] (1-12). In the five children treated by hemodialysis, the blood and dialysate flow rates were 6 mL/kg/min [5-7] (4-7) and 600 mL/h [300-600] (120-600), respectively, while session duration was 8 h [6-12] (2-24). Most infants required a catheter between 4.5 and 6.5 French. Hemodynamic instability with a need for volume replacement occurred in 31 sessions (23%). Thrombocytopenia was observed in 29 sessions (22%). No hemorrhage occurred; all the patients survived the sessions, but only eight patients (32%) were alive at hospital discharge.
conclusionsThese data confirm that the use of CARPEDIEM® is safe and effective in critically ill neonates and infants. A higher resolution version of the Graphical abstract is available as Supplementary information.
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