Evidence map›Paper›PMID 36625843›Full record

ReviewCancer research2023

Challenges to Using Big Data in Cancer.

Shawn M Sweeney, Hisham K Hamadeh, Natalie Abrams, Stacey J Adam, Sara Brenner, Dana E Connors, Gerard J Davis, Louis Fiore, Susan H Gawel, Robert L Grossman and 20 more

Abstract readReview
In one paragraph

Review in Cancer research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Current trends and future directions of artificial intelligence in lung cancer diagnosis.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Imaging genomics of cancer: a bibliometric analysis and review.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Review
  14. Quality of care assessment for non-small cell lung cancer patients: transforming routine care data into a continuous improvement system.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Observational
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Shawn M SweeneyAmerican Association for Cancer Research, Philadelphia, Pennsylvania.ORCID 0000-0002-4269-6566
Hisham K HamadehGenmab, Princeton, New Jersey.ORCID 0000-0002-6800-2120
Natalie AbramsDivision of Cancer Prevention, Early Detection Research Network, National Cancer Institute, Rockville, Maryland.ORCID 0000-0001-9698-2819
Stacey J AdamFoundation for the National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-4590-5175
Sara BrennerOffice of In Vitro Diagnostics, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland.ORCID 0000-0002-0999-7674
Dana E ConnorsFoundation for the National Institutes of Health, Bethesda, Maryland.ORCID 0000-0001-7930-6843
Gerard J DavisAbbott Diagnostics Division, Abbott Laboratories, Lake Forest, Illinois.ORCID 0000-0002-4149-1999
Louis FioreBoston University School of Medicine, Boston and New England Department of Veterans Affairs, Bedford, Massachusetts.ORCID 0000-0002-2195-5186
Susan H GawelAbbott Diagnostics Division, Abbott Laboratories, Lake Forest, Illinois.ORCID 0000-0003-3295-7539
Robert L GrossmanCenter for Translational Data Science, The University of Chicago, Chicago, Illinois.ORCID 0000-0003-3741-5739
Sean E HanlonCenter for Strategic Scientific Initiatives, National Cancer Institute, Bethesda, Maryland.ORCID 0000-0001-6899-6906
Karl HsuSanofi, Bridgewater, New Jersey.ORCID 0000-0003-3137-1202
Gary J KelloffDivision of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland.ORCID 0000-0002-5656-4900
Ilan R KirschAdaptive Biotechnologies, Seattle, Washington.ORCID 0000-0001-5592-5201
Bill LouvProject Data Sphere, Morrisville, North Carolina.ORCID 0000-0002-2789-4994
Deven McGrawCiitizen Platform at Invitae, San Francisco, California.ORCID 0000-0002-8172-4400
Frank MengBoston University and Veterans Administration Boston Healthcare System, Boston, Massachusetts.ORCID 0000-0002-3065-1619
Daniel MilgramCCS Associates, San Jose, California.ORCID 0000-0001-7287-9307
Robert S MillerCancerLinQ, American Society of Clinical Oncology, Alexandria, Virginia.ORCID 0000-0003-0869-6316
Emily MorganFoundation for the National Institutes of Health, Bethesda, Maryland.ORCID 0000-0003-2031-4341
Lata MukundanCCS Associates, San Jose, California.ORCID 0000-0002-7608-3557
Thomas O'BrienPfizer, Brooklyn, New York.ORCID 0000-0002-9161-8070
Paul RobbinsPfizer, Brooklyn, New York.ORCID 0000-0003-3704-4616
Eric H RubinMerck, New York, New York.ORCID 0000-0002-8032-7913
Wendy S RubinsteinOffice of In Vitro Diagnostics, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland.
Liz SalmiBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0003-3798-7438
Teilo SchallerProject Data Sphere, Morrisville, North Carolina.ORCID 0000-0002-5036-5820
George ShiAbbott Diagnostics Division, Abbott Laboratories, Lake Forest, Illinois.ORCID 0000-0001-5689-9359
Caroline C SigmanBoston University and Veterans Administration Boston Healthcare System, Boston, Massachusetts.ORCID 0000-0001-6623-4107
Sudhir SrivastavaCancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, Maryland.ORCID 0000-0002-7798-9772

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Big data in healthcare can enable unprecedented understanding of diseases and their treatment, particularly in oncology. These data may include electronic health records, medical imaging, genomic sequencing, payor records, and data from pharmaceutical research, wearables, and medical devices. The ability to combine datasets and use data across many analyses is critical to the successful use of big data and is a concern for those who generate and use the data. Interoperability and data quality continue to be major challenges when working with different healthcare datasets. Mapping terminology across datasets, missing and incorrect data, and varying data structures make combining data an onerous and largely manual undertaking. Data privacy is another concern addressed by the Health Insurance Portability and Accountability Act, the Common Rule, and the General Data Protection Regulation. The use of big data is now included in the planning and activities of the FDA and the European Medicines Agency. The willingness of organizations to share data in a precompetitive fashion, agreements on data quality standards, and institution of universal and practical tenets on data privacy will be crucial to fully realizing the potential for big data in medicine.

Indexed as

Big DataNeoplasmsHumansInformation Storage and RetrievalPrecision Medicine

Identifiers

PMID36625843
PMCPMC10102837

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.