Evidence map›Paper›PMID 36625437›Full record

ArticleDrug delivery2023

MPET

Hao Wang, Tianyi Hu, Yu Leng, Mario de Lucio, Hector Gomez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hao WangSchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.ORCID 0000-0003-4048-0718
Tianyi HuSchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
Yu LengSchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
Mario de LucioSchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
Hector GomezSchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
Purdue University West Lafayette · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subcutaneous injection of monoclonal antibodies (mAbs) has attracted much attention in the pharmaceutical industry. During the injection, the drug is delivered into the tissue producing strong fluid flow and tissue deformation. While data indicate that the drug is initially uptaken by the lymphatic system due to the large size of mAbs, many of the critical absorption processes that occur at the injection site remain poorly understood. Here, we propose the MPET

Indexed as

Antibodies, MonoclonalLymphatic VesselsComputer SimulationInjections, SubcutaneousLymphatic SystemAntibodies, Monoclonalbiomechanical modelingmonoclonal antibodiesmulti-network poroelastic (MPET) modelsubcutaneous biomechanicsSubcutaneous injection

Identifiers

PMID36625437
PMCPMC9851243
OpenAlexW4315436529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.