Evidence map›Paper›PMID 36625271›Full record

ArticleJournal of primary care & community health

Sedative-hypnotic Co-prescribing with Opioids in a Large Network of Community Health Centers.

Daniel M Hartung, Jennifer A Lucas, Nathalie Huguet, Steffani R Bailey, Jean O'Malley, Robert W Voss, Irina Chamine, John Muench

Open access · goldAbstract read
In one paragraph

Article in Journal of primary care & community health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Daniel M HartungOregon State University, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0002-0685-773X
Jennifer A LucasOregon Health & Science University, Portland, OR, USA.
Nathalie HuguetOregon Health & Science University, Portland, OR, USA.ORCID 0000-0002-4064-1553
Steffani R BaileyOregon Health & Science University, Portland, OR, USA.
Jean O'MalleyOCHIN, Portland, OR, USA.
Robert W VossOCHIN, Portland, OR, USA.
Irina ChamineOregon Health & Science University, Portland, OR, USA.
John MuenchOregon Health & Science University, Portland, OR, USA.
Oregon Health & Science University · USOchin · USOregon State University · US

Funding

EpiCenter ? EPIdemiology of opioid prescribing in community health CENTERsR01DA046468 · NIDA · OREGON STATE UNIVERSITY · PI HARTUNG, DANIEL M · 2018 to 2022
$2.5M
Cellular Activation Pathways in Rheumatoid ArthritisR01AR046468 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLOSHITZ, JOSEPH · 2001 to 2004
$1.0M
NIAMS NIH HHS R01 AR046468NIDA NIH HHS R01 DA046468
6 · The paper itself

Abstract

objectiveWhen prescribed with opioids, sedative-hypnotics substantially increase the risk of overdose. The objective of this paper was to describe characteristics and trends in opioid sedative-hypnotic co-prescribing in a network of safety-net clinics serving low-income, publicly insured, and uninsured individuals.

methodsThis retrospective longitudinal analysis of prescription orders examined opioid sedative-hypnotic co-prescribing rates between 2009 and 2018 in the OCHIN network of safety-net community health centers. Sedative-hypnotics included benzodiazepine and non-benzodiazepine sedatives (eg, zolpidem). Co-prescribing patterns were assessed overall and across patient demographic and co-morbidity characteristics.

resultsFrom 2009 to 2018, 240 587 patients had ≥1 opioid prescriptions. Most were White (65%), female (59%), and had Medicaid insurance (43%). One in 4 were chronic opioid users (25%). During this period, 55 332 (23%) were co-prescribed a sedative-hypnotic. The prevalence of co-prescribing was highest for females (26% vs 19% for males), non-Hispanic Whites (28% vs 13% for Hispanic to 20% for unknown), those over 44 years of age (25% vs 20% for <44 years), Medicare insurance (30% vs 21% for uninsured to 22% for other/unknown), and among those on chronic opioid therapy (40%). Co-prescribing peaked in 2010 (32%) and declined steadily through 2018 (20%). Trends were similar across demographic subgroups. Co-prescribed sedative-hypnotics remained elevated for those with chronic opioid use (27%), non-Hispanic Whites (24%), females (23%), and those with Medicare (23%) or commercial insurance (22%).

conclusionsCo-prescribed sedative-hypnotic use has declined steadily since 2010 across all demographic subgroups in the OCHIN population. Concurrent use remains elevated in several population subgroups.

Indexed as

Analgesics, OpioidMedicareAdultAgedBenzodiazepinesFemaleHumansHypnotics and SedativesMaleRetrospective StudiesUnited StatesAnalgesics, OpioidBenzodiazepinesHypnotics and Sedativesbenzodiazepinesopioidssedative-hypnotics

Identifiers

PMID36625271
PMCPMC9834924
OpenAlexW4315436757

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.