Evidence map›Paper›PMID 36625171›Full record

ArticleJournal of Korean medical science2023

Diagnostic Usefulness of Varicella Zoster Virus-Specific Immunoglobulin (Ig) A and IgG in Patients With Herpes Zoster.

Sungim Choi, Song Mi Moon, Ji-Soo Kwon, Sung-Han Kim, Seong Yeon Park

Abstract read
In one paragraph

Article in Journal of Korean medical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sungim Choi *Department of Infectious Diseases, Dongguk University Ilsan Hospital, Goyang, Korea.ORCID https://orcid.org/0000-0001-8692-5570
Song Mi Moon *Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0003-1241-4895
Ji-Soo KwonDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-6945-6100
Sung-Han KimDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-6596-8253
Seong Yeon ParkDepartment of Infectious Diseases, Dongguk University Ilsan Hospital, Goyang, Korea. psy99ch@hanmail.net.ORCID https://orcid.org/0000-0001-8762-7006

Funding

Dongguk UniversityNational Research Foundation of Korea NRF-2017R1C1B2003336
6 · The paper itself

Abstract

backgroundWhether varicella zoster virus (VZV) antibody titer could discriminate patients with herpes zoster (HZ) from healthy controls (HCs) is unclear. We evaluated the diagnostic usefulness of VZV-specific immunoglobulin A (IgA) and immunoglobulin G (IgG) antibodies in patients with confirmed HZ.

methodsStudy subjects comprised patients with confirmed HZ by salivary VZV DNA positivity and control age- and sex-matched HCs. Saliva was collected and concurrent blood samples were obtained on the first visit day (acute phase) and after 4 weeks (convalescent phase) from 44 HZ patients. All 44 healthy volunteers provided blood and saliva samples once.

resultsThe median VZV IgA titers in acute-phase (5.2 mIU/mL,

conclusionVZV IgA positivity or four-fold or higher increase in VZV IgG antibody titers were not detected in a satisfactory proportion of HZ-infected patients. However, the titer of VZV IgA or IgG antibody particularly in convalescent-phase sera may discriminate HZ patients from HCs.

Indexed as

Herpesvirus 3, HumanHerpes ZosterAntibodies, ViralHumansImmunoglobulin AImmunoglobulin GAntibodies, ViralImmunoglobulin AImmunoglobulin GHerpes ZosterVaricella Zoster Virus (VZV)VZV Immunoglobulin AVZV Immunoglobulin G

Identifiers

PMID36625171
PMCPMC9829510

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.