ArticleThe Journal of organic chemistry2023
A Method for Converting HPLC Peak Area from Online Reaction Monitoring to Concentration Using Nonlinear Regression.
Article in The Journal of organic chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Calibration-free reaction yield quantification by HPLC with a machine-learning model of extinction coefficients.Chemical science · 2024Article
- Reaction Kinetics using a Chemputable Framework for Data Collection and Analysis.Angewandte Chemie (International ed. in English) · 2024Article
- Parallel multi-droplet platform for reaction kinetics and optimization.Chemical science · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Online HPLC reaction progress monitoring provides detailed data-rich profiles; however, extracting kinetic information requires ultraviolet-visible response factors to determine concentrations from peak areas. If the reaction's overall mass balance is known and some analytical trend for all relevant species can be recorded, it is possible to estimate the absolute response factors of all species using a system of linear equations. We delineate a method using the Microsoft Solver plug-in to convert time course profiles to reagent concentrations without analytical standards.
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Registered trials
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