SynthesisCartilage2023
Prognostic Factors for the Clinical Outcome after Microfracture Treatment of Chondral and Osteochondral Defects in the Knee Joint: A Systematic Review.
Synthesis in Cartilage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Differential analysis of the impact of lesions' location on clinical and radiological outcomes after the implantation of a novel aragonite-based scaffold to treat knee cartilage defects.International orthopaedics · 2024Trial
- Prognostic factors associated with outcomes after knee cartilage repair across different procedure types: a systematic review.Knee surgery & related research · 2026Review
- A Systematic Review on Amnion as a Cell Delivery Scaffolding Material for Cartilage Regeneration in Pre-Clinical and Clinical Studies.Bioengineering (Basel, Switzerland) · 2026Review
- Prior procedures, graft location, preoperative physical health, postoperative strength and graft integrity are associated with 10-year clinical outcome after matrix-induced autologous chondrocyte implantation.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Effectiveness of platelet-rich plasma plus microfracture compared with microfracture alone in the treatment of knee cartilage lesions: a systematic review and meta-analysis of comparative studies.International journal of surgery (London, England) · 2026Article
- Algorithm-Based Surgical Decision-Making for Focal Knee Cartilage Defects: A Pragmatic Clinical Framework with Illustrative Cases.Orthopedic reviews · 2026Article
- Clinical Benefits of Cartilage Repair in High Tibial Osteotomy Can Only Be Expected in Patients with Successfully Regenerated Cartilage.Clinics in orthopedic surgery · 2025Article
- The collagen-augmented chondrogenesis technique demonstrates superior cartilage repair compared to microfracture for cartilage defects of the knee joint, regardless of age.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Knee focal cartilage defect location heat map and local surface morphology characterisation: Insights for focal knee resurfacing implant design.Journal of experimental orthopaedics · 2025Article
- Osteochondral solutions for cartilage lesions of the knee: a narrative review.Annals of joint · 2025Review
- Osteoperiosteal Cylindrical Iliac Bone Graft and Minced Cartilage as an Osteochondral Autograft for a Large Osteochondral Lesion.Arthroscopy techniques · 2024Article
- Article
- Pediatric osteochondral fractures: clinical insights associate early diagnosis to early rehabilitation via arthroscopy.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Observational
- Return to Play After Knee Articular Cartilage Restoration: Surgical Options, Rehabilitation Protocols, and Performance Outcomes.Current reviews in musculoskeletal medicine · 2023Review
- Cartilage Defect Treatment Using High-Density Autologous Chondrocyte Implantation (HD-ACI).Bioengineering (Basel, Switzerland) · 2023Review
- Treatment of Chondral Lesions in the Knee.Revista brasileira de ortopedia · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study is to establish which patient and lesion characteristics are related to the clinical outcome after microfracture of cartilage defects in the knee. STUDY
designSystematic review.
methodsAfter preregistration, PubMed, Embase, and Cochrane were searched for studies that analyzed prognostic factors for the outcome of microfracture treatment in the knee. The criteria for inclusion were outcome measured using Patient-Reported Outcome Measures (PROMs), a clinical study with ≥10 participants receiving microfracture, and a minimal follow-up period of 1 year.
resultsFor none of the investigated prognostic factors, effect size reporting was sufficiently homogeneous to conduct a meta-analysis. However, a majority of the included studies identified higher age, larger lesion size, longer preoperative symptom duration, and previous surgery on the ipsilateral knee, especially meniscectomy and anterior cruciate ligament reconstruction, as factors that are reported to be correlated to a less favorable outcome. A lesion location that does not include the trochlea or the patellofemoral joint and is not weightbearing, a nondegenerative mechanism of injury, and a single lesion were reported as factors that predict a favorable outcome. As to gender, body mass index, preoperative activity level, smoking, and concomitant knee surgery, the included articles were inconclusive or no effect was reported.
conclusionsSeveral factors correlated with the clinical result after microfracture treatment. However, the information on the effect sizes of the influence on clinical outcome is incomplete due to poor reporting. Large-scale registries or pooling of homogeneous, well-reported data is needed to work toward prognostic models. That would be an important step toward personalized treatment.
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