Evidence map›Paper›PMID 36624888›Full record

ArticleBrain, behavior, & immunity - health2023

Associations of subjective and objective cognitive functioning after COVID-19: A six-month follow-up of ICU, ward, and home-isolated patients.

Riikka E Pihlaja, Lina-Lotta S Kauhanen, Henriikka S Ollila, Annamari S Tuulio-Henriksson, Sanna K Koskinen, Marjaana Tiainen, Viljami R Salmela, Johanna Hästbacka, Laura S Hokkanen

Open access · goldAbstract read
In one paragraph

Article in Brain, behavior, & immunity - health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Neurocognitive Impairment in Long COVID: A Systematic Review.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
    Pooled it
  2. Profiles of Individuals With Long COVID Reporting Persistent Cognitive Complaints.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Riikka E PihlajaDepartment of Psychology and Logopaedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Lina-Lotta S KauhanenDepartment of Psychology and Logopaedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Henriikka S OllilaDepartment of Anaesthesiology, Intensive Care and Pain Medicine, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Annamari S Tuulio-HenrikssonDepartment of Psychology and Logopaedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Sanna K KoskinenDepartment of Psychology and Logopaedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Marjaana TiainenDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Viljami R SalmelaDepartment of Psychology and Logopaedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Johanna HästbackaDepartment of Anaesthesiology, Intensive Care and Pain Medicine, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Laura S HokkanenDepartment of Psychology and Logopaedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
University of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Subjective and objective cognitive dysfunction are reported after COVID-19 but with limited data on their congruence and associations with the severity of the acute disease. The aim of this cohort study is to describe the prevalence of subjective and objective cognitive dysfunction at three and six months after COVID-19 and the associations of subjective cognitive symptoms and psychological and disease-related factors. Methods: We assessed a cohort of 184 patients at three and six months after COVID-19: 82 patients admitted to the Intensive Care Unit (ICU), 53 admitted to regular hospital wards, and 49 isolated at home. A non-COVID control group of 53 individuals was included. Demographic and clinical data were collected. Subjective cognitive symptoms, objective cognitive impairment, and depressive and post-traumatic stress disorder (PTSD) symptoms were assessed. Results: At six months, subjective cognitive impairment was reported by 32.3% of ICU-treated, 37.3% of ward-treated, and 33.3% of home-isolated patients and objective cognitive impairment was observed in 36.1% of ICU-treated, 34.7% of ward-treated, and 8.9% of home-isolated patients. Subjective cognitive symptoms were associated with depressive and PTSD symptoms and female sex, but not with objective cognitive assessment or hospital metrics. Conclusions: One-third of COVID-19 patients, regardless of the acute disease severity, reported high levels of subjective cognitive dysfunction which was not associated with results from objective cognitive screening but with psychological and demographic factors. Our study stresses the importance of thorough assessment of patients reporting long-term subjective symptoms, screening for underlying mental health related factors such as PTSD or depression.

Indexed as

Cognitive dysfunctionCOVID-19Subjective cognitive symptoms

Identifiers

PMID36624888
PMCPMC9812472
OpenAlexW4313596540

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.