Evidence map›Paper›PMID 36624686›Full record

ArticleBrain and behavior2023

Are brain MRI abnormalities associated with the semiology of functional seizures?

Ali A Asadi-Pooya, Wesley T Kerr, Ioannis Karakis, Kousuke Kanemoto, Anilu Daza-Restrepo, Mohsen Farazdaghi, Faith J Horbatch, Nicholas J Beimer, Dawn E Eliashiv, Aida Risman and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ali A Asadi-PooyaEpilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID 0000-0002-2598-7601
Wesley T KerrDepartment of Neurology, University of Michigan, Ann Arbor, Michigan.
Ioannis KarakisDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia.
Kousuke KanemotoNeuropsychiatric Department, Aichi Medical University, Nagakute, Aichi, Japan.
Anilu Daza-RestrepoENyS CONICET - Neuroscience and Epilepsy Service, El Cruce Hospital "Dr. Néstor Kirchner,", Buenos Aires, Argentina.
Mohsen FarazdaghiEpilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Faith J HorbatchDepartment of Neurology, University of Michigan, Ann Arbor, Michigan.
Nicholas J BeimerDepartment of Neurology, University of Michigan, Ann Arbor, Michigan.
Dawn E EliashivDepartment of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, California.
Aida RismanDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia.
Yuko SugimotoNeuropsychiatric Department, Aichi Medical University, Nagakute, Aichi, Japan.
Brenda GiaganteENyS CONICET - Neuroscience and Epilepsy Service, El Cruce Hospital "Dr. Néstor Kirchner,", Buenos Aires, Argentina.

Funding

Translational Neuroscience Training GrantR25NS065723 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARMICHAEL, STANLEY THOMAS · 2009 to 2023
$2.8M
UM Clinical Neuroscientist Training ProgramR25NS089450 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2014 to 2023
$1.3M
NINDS NIH HHS R25 NS065723NINDS NIH HHS R25 NS089450
6 · The paper itself

Abstract

purposeTo investigate whether radiologically apparent brain magnetic resonance imaging (MRI) abnormalities are associated with the functional seizure (FS) semiology.

methodsAll patients with a diagnosis of FS at the epilepsy centers at Shiraz University of Medical Sciences, Iran; Aichi Medical University Hospital, Japan; University of Michigan, USA; University of California, Los Angeles, USA; Emory University School of Medicine, USA; and Hospital el Cruce, Argentina, were studied.

resultsOne hundred patients were included; 77 (77%) had motor functional seizures. Lobar location of brain abnormality did not have an association with the semiology (p = .83). There was no significant difference between ictal behaviors in patients with frontal or parietal lesions compared to those with temporal or occipital lesions.

conclusionThere were no associations between functional seizure ictal behaviors and locations of the radiologically apparent brain MRI abnormalities. Further studies are needed to evaluate the underpinnings of varying behaviors in FS.

Indexed as

Brain DiseasesElectroencephalographyBrainHumansMagnetic Resonance ImagingRetrospective StudiesSeizuresmagnetic resonance imaging (MRI)neuropsychiatricspsychiatric disorders

Identifiers

PMID36624686
PMCPMC9927836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.