ArticleMicrobiome2023
The bovine foot skin microbiota is associated with host genotype and the development of infectious digital dermatitis lesions.
Article in Microbiome, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Hoof, Vaginal and Milk Microbiota Alterations in Dairy Cows with Foot Rot.Animals : an open access journal from MDPI · 2026Article
- Application of 16S rRNA gene amplicon sequencing in the investigation of novel ovine skin lesions in Norway.Frontiers in veterinary science · 2026Article
- The Microbial Composition of Bovine Colostrum as Influenced by Antibiotic Treatment.Antibiotics (Basel, Switzerland) · 2025Article
- Article
- Clinical and diagnostic comparisons of bovine foot rot and bovine digital dermatitis lesions and management differences in feedlot cattle in Alberta.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- A Global Comparative Genomic Analysis of Major Bacterial Pathogens in Bovine Mastitis and Lameness.Animals : an open access journal from MDPI · 2025Review
- Unravelling the complexity of bovine milk microbiome: insights into mastitis through enterotyping using full-length 16S-metabarcoding.Animal microbiome · 2024Article
- Characterization of the Hoof Bacterial Communities of Active Digital Dermatitis Lesions in Feedlot Cattle.Microorganisms · 2024Article
- Discovery of novel treponemes associated with pododermatitis in elk (Applied and environmental microbiology · 2024Article
- Unveiling genetic signatures associated with resilience to neonatal diarrhea in lambs through two GWAS approaches.Scientific reports · 2024Article
- Mendelian randomization analysis of 34,497 German Holstein cows to infer causal associations between milk production and health traits.Genetics, selection, evolution : GSE · 2024Article
- Exploring the Influence of Growth-Associated Host Genetics on the Initial Gut Microbiota in Horses.Genes · 2023Article
- Genetic parameters of sole lesion recovery in Holstein cows.Journal of dairy science · 2023Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 3 countries.
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Abstract
backgroundBovine Digital Dermatitis (BDD) is a prevalent infectious disease, causing painful foot skin lesions and lameness in cattle. We describe herein the bovine foot skin microbiota and its associations with BDD using 16S rRNA gene amplicon and shotgun metagenomic sequencing on samples from 259 dairy cows from three UK dairy farms.
resultsWe show evidence of dysbiosis, and differences in taxonomy and functional profiles in the bovine foot skin microbiome of clinically healthy animals that subsequently develop BDD lesions, compared to those that do not. Our results suggest that taxonomical and functional differences together with alterations in ecological interactions between bacteria in the normal foot skin microbiome may predispose an animal to develop BDD lesions. Using genome-wide association and regional heritability mapping approaches, we provide first evidence for interactions between host genotype and certain members of the foot skin microbiota. We show the existence of significant genetic variation in the relative abundance of Treponema spp. and Peptoclostridium spp. and identify regions in the bovine genome that explain a significant proportion of this variation.
conclusionsCollectively this work shows early changes in taxonomic and functional profiles of the bovine foot-skin microbiota in clinically healthy animals which are associated with subsequent development of BDD and could be relevant to prevention of disease. The description of host genetic control of members of the foot skin microbiota, combined with the association of the latter with BDD development offer new insights into a complex relationship that can be exploited in selective breeding programmes. Video Abstract.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.