Evidence map›Paper›PMID 36624475›Full record

ArticleCell & bioscience2023

Knockout of secretin ameliorates biliary and liver phenotypes during alcohol-induced hepatotoxicity.

Konstantina Kyritsi, Nan Wu, Tianhao Zhou, Guido Carpino, Leonardo Baiocchi, Lindsey Kennedy, Lixian Chen, Ludovica Ceci, Alison Ann Meyer, Nipuni Barupala and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 2 countries.

Konstantina Kyritsi *Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Nan Wu *Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Tianhao Zhou *Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Guido CarpinoDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, La Sapienza University of Rome, Rome, Italy.
Leonardo BaiocchiUnit of Hepatology, Tor Vergata University, Rome, Italy.
Lindsey KennedyDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Lixian ChenDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Ludovica CeciDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Alison Ann MeyerDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Nipuni BarupalaDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Antonio FranchittoDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.
Paolo OnoriDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, La Sapienza University of Rome, Rome, Italy.
Burcin EkserDivision of Transplant Surgery, Department of Surgery, Indiana University, Indianapolis, IN, USA.
Eugenio GaudioDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, La Sapienza University of Rome, Rome, Italy.
Chaodong WuDepartment of Nutrition, Texas A&M University, College Station, TX, USA.
Corinn MarakovitsDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Sanjukta ChakrabortyDepartment of Medical Physiology, Texas A&M University School of Medicine, 8447 Riverside Parkway, MREB II, Room 2342, Bryan, TX, 77807-3260, USA.
Heather FrancisDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. heafranc@iu.edu.
Shannon GlaserDepartment of Medical Physiology, Texas A&M University School of Medicine, 8447 Riverside Parkway, MREB II, Room 2342, Bryan, TX, 77807-3260, USA. sglaser@tamu.edu.
Gianfranco AlpiniDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. galpini@iu.edu.ORCID http://orcid.org/0000-0002-6658-3021
Indiana University School of MedicineRichard L. Roudebush VA Medical Center · USSapienza University of Rome · ITTexas A&M University · USForo Italico University of Rome · ITIndiana University – Purdue University Indianapolis · USTexas A&M Health Science Center · USUniversity of Rome Tor Vergata · IT

Funding

GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREER01DK054811 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2000 to 2021
$3.8M
The Paracrine Regulation of Mast Cells During Biliary/Cholangiocyte Repair and DamageR01DK108959 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI FRANCIS, HEATHER L · 2016 to 2024
$2.5M
Alcohol-induced hepatotoxicity - implications of secretin/secretin receptor axisR01AA028711 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2020 to 2023
$2.2M
Regulation of Bile Duct Growth in Bile Duct Ligated RatsR01DK062975 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2005 to 2014
$1.9M
Role of Sensory Neuropeptides in the Regulation of Biliary FunctionR01DK076898 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2008 to 2016
$1.8M
The Role of Stem Cell Derived Microvesicles in Cholestatic Liver InjuryR01DK107310 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2015 to 2019
$1.7M
Mechanisms of mast cell/cholangiocyte regulation of non-alcoholic fatty liver disease progressionR01DK119421 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI FRANCIS, HEATHER L · 2019 to 2022
$1.4M
Neuroendocrine Regulation of Biliary Growth and FibrosisR01DK110035 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2017 to 2020
$1.2M
Regulation of biliary growth and fibrosis by melatoninR01DK115184 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2017 to 2020
$1.2M
REGULATION OF CELLULAR SENESCENCE BY NON-CODING RNAS IN ALCOHOLIC LIVER INJURYR21AA025997 · NIAAA · SCOTT AND WHITE MEMORIAL HOSPITAL · PI ALPINI, GIANFRANCO D, MENG, FANYIN · 2017 to 2018
$435k
Role of stem cell derived microvesicles in alcoholic liver injuryR21AA025157 · NIAAA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, MENG, FANYIN · 2017 to 2018
$350k
BLR&D Research Career Scientist AwardIK6BX004601 · VA · RLR VA MEDICAL CENTER · PI ALPINI, GIANFRANCO D · 2019 to 2025
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BLRD VA I01 BX000574BLRD VA I01 BX003031BLRD VA IK2 BX005306BLRD VA IK6 BX004601BLRD VA IK6 BX005226NIAAA NIH HHS AA025157NIAAA NIH HHS AA025997NIAAA NIH HHS R01 AA028711NIDDK NIH HHS DK054811NIDDK NIH HHS DK062975NIDDK NIH HHS DK076898NIDDK NIH HHS DK107310NIDDK NIH HHS DK108959NIDDK NIH HHS DK110035NIDDK NIH HHS DK115184NIDDK NIH HHS DK119421NIDDK NIH HHS R01 DK054811NIDDK NIH HHS R01 DK062975NIDDK NIH HHS R01 DK076898NIDDK NIH HHS R01 DK107310NIDDK NIH HHS R01 DK108959NIDDK NIH HHS R01 DK110035NIDDK NIH HHS R01 DK115184NIDDK NIH HHS R01 DK119421
6 · The paper itself

Abstract

backgroundAlcohol-related liver disease (ALD) is characterized by ductular reaction (DR), liver inflammation, steatosis, fibrosis, and cirrhosis. The secretin (Sct)/secretin receptor (SR) axis (expressed only by cholangiocytes) regulates liver phenotypes in cholestasis. We evaluated the role of Sct signaling on ALD phenotypes.

methodsWe used male wild-type and Sct

resultsIn EtOH-fed WT mice there was increased biliary and liver damage compared to control mice, but decreased miR-125b expression, phenotypes that were blunted in EtOH-fed Sct

conclusionsTargeting Sct/SR signaling may be important for modulating ALD phenotypes.

Indexed as

Biliary senescenceDuctular reactionFatty liver diseasesHepatic steatosisLipogenesis

Identifiers

PMID36624475
PMCPMC9830859
OpenAlexW4315436495

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.