ArticleBMC endocrine disorders2023
Age and sex trend differences in hemoglobin levels in China: a cross-sectional study.
Article in BMC endocrine disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Altitude-Related Laboratory Changes and a Novel Hemoglobin Estimation Model: A Retrospective Analysis in Children and Adults.International journal of laboratory hematology · 2026Article
- Demographics, clinical features, and comorbidities of high-altitude polycythaemia: a multicentre, retrospective, observational study.Journal of global health · 2026Observational
- Clinical Impact of Red Blood Cell Transfusion Location on Gastrointestinal Bleeding Outcomes: Emergency Department vs. Inpatient Unit.Healthcare (Basel, Switzerland) · 2025Article
- Research on related factors of hyperuricemia in high altitude area migrant population.Frontiers in endocrinology · 2025Article
- Increased Incidence and Clinical Features of Septic Arthritis in Patients Aged 80 Years and above: A Comparative Analysis with Younger Cohorts.Pathogens (Basel, Switzerland) · 2024Article
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10 authors.
Funding
Abstract
backgroundBoth age and gender are the influence factors of hemoglobin concentration. However, the changing trend of hemoglobin levels between males and females with age remains unclear. This study aimed to explore their changing characteristics in different genders.
methodsA cross-sectional study was conducted in Physical Examination Center of the First Affiliated Hospital of Wannan Medical College in Wuhu, China from 2014 to 2016. The generalized linear model was applied to explore the relationship between age, gender and hemoglobin levels.
resultsAmong the 303,084 participants, the mean age for females and males was 46.9 ± 13.4(15-98) and 48.1 ± 13.7(14-98) years old, respectively. Generalized smoothing splines showed that hemoglobin levels increased up to age 25 and then decreased in men; in women the levels increased up until age 20, and then decreased, with slight increase again (β = 0.244, P < 0.01). After dividing all participants into hyperglycemia and normal groups, only the normal female group showed a significant upward trend (β = 0.257, P < 0.01) between ages 50-59.
conclusionsHemoglobin concentration changes with age and the curve is different in males and females. The slightly upward trend of female hemoglobin in the age range of 50-59 years old should be considered in developing the reference range of hemoglobin making.
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