Evidence map›Paper›PMID 36624460›Full record

ArticleTrials2023

Pragmatic cluster randomized trial to evaluate effectiveness and implementation of EHR-facilitated collaborative symptom control in cancer (E2C2): addendum.

Jeph Herrin, Lila J Finney Rutten, Kathryn J Ruddy, Kurt Kroenke, Andrea L Cheville

Abstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Identifying the trajectory of SPPADE symptoms in patients with cancer using electronic health record data.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jeph HerrinYale University School of Medicine, New Haven, CT, USA. jeph.herrin@yale.edu.ORCID http://orcid.org/0000-0002-3671-3622
Lila J Finney RuttenMedical Affairs, Exact Sciences, Madison, WI, USA.
Kathryn J RuddyDivision of Medical Oncology, Mayo Clinic, Rochester, MN, USA.
Kurt KroenkeIndiana University School of Medicine, Indianapolis, IN, USA.
Andrea L ChevilleRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.

Funding

Enhanced, EHR-facilitated Cancer Symptom Control (E2C2) Pragmatic Clinical TrialUM1CA233033 · NCI · MAYO CLINIC ROCHESTER · PI CHEVILLE, ANDREA LYNNE · 2018 to 2018
$8.7M
NCI NIH HHS UM1 CA233033
6 · The paper itself

Abstract

We previously described the hypotheses, outcomes, design, and analysis for E2C2, a pragmatic stepped-wedge trial to assess an intervention to improve symptom control in patients with cancer. Subsequent consideration of the design and cohort led to the addition of a second primary hypothesis. This article describes and presents the rationale for this second hypothesis. This addendum also details a revised analytic approach, necessitated by inconsistencies in the original analytic plan. The design, outcomes, and other aspects of the protocol remain unchanged.

Indexed as

NeoplasmsHumansPragmatic Clinical Trials as TopicRandomized Controlled Trials as TopicElectronic health recordNeoplasmPainPalliative carePatient care teamPatient-reported outcome measureQuality of lifeSelf-managementSurvivorSystems integration

Identifiers

PMID36624460
PMCPMC9830868

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.