Evidence map›Paper›PMID 36624381›Full record

ArticleBMC genomics2023

Characterization of Danube Swabian population samples on a high-resolution genome-wide basis.

Zsolt Bánfai, Erzsébet Kövesdi, Katalin Sümegi, Gergely Büki, András Szabó, Lili Magyari, Valerián Ádám, Ferenc Pálos, Attila Miseta, Miklós Kásler and 1 more

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Article in BMC genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

11 authors.

Zsolt BánfaiDepartment of Medical Genetics, Medical School, University of Pécs, Szigeti út 12, H-7624, Pécs, Hungary. banfai.zsolt@pte.hu.
Erzsébet KövesdiSzentágothai Research Centre, University of Pécs, Ifjúság út 20, H-7624, Pécs, Hungary.
Katalin SümegiDepartment of Medical Genetics, Medical School, University of Pécs, Szigeti út 12, H-7624, Pécs, Hungary.
Gergely BükiDepartment of Medical Genetics, Medical School, University of Pécs, Szigeti út 12, H-7624, Pécs, Hungary.
András SzabóDepartment of Medical Genetics, Medical School, University of Pécs, Szigeti út 12, H-7624, Pécs, Hungary.
Lili MagyariDepartment of Medical Genetics, Medical School, University of Pécs, Szigeti út 12, H-7624, Pécs, Hungary.
Valerián ÁdámDepartment of Medical Genetics, Medical School, University of Pécs, Szigeti út 12, H-7624, Pécs, Hungary.
Ferenc PálosDepartment of Medical Genetics, Medical School, University of Pécs, Szigeti út 12, H-7624, Pécs, Hungary.
Attila MisetaDepartment of Laboratory Medicine, Medical School, University of Pécs, Ifjúság út 13, H-7624, Pécs, Hungary.
Miklós KáslerNational Institute of Oncology, Ráth György u. 7-9, H-1122, Budapest, Hungary.
Béla MeleghDepartment of Medical Genetics, Medical School, University of Pécs, Szigeti út 12, H-7624, Pécs, Hungary. melegh.bela@pte.hu.

Funding

National Scientific Research Program (NKFI) K 138669
6 · The paper itself

Abstract

backgroundGerman-derived ethnicities are one of the largest ethnic groups in Hungary, dating back to the formation of the Kingdom of Hungary, which took place at the beginning of the 11th century. Germans arrived in Hungary in many waves. The most significant immigration wave took place following the collapse of the Ottoman Empire in East-Central Europe which closed the 150 year long Ottoman occupation. To date, there are no comprehensive genome-wide studies investigating the genetic makeup of the Danube Swabians. Here we analyzed 47 Danube Swabian samples collected from elderly Swabian individuals living in the Dunaszekcső-Bár area, in Danube side villages of Southwest Hungary. These Swabians, according to self-declaration, did not admix with other ethnic groups for 3-6 succeeding generations. Using Illumina Infinium 720 K Beadchip genotype data, we applied allele frequency-based and haplotype-based genome-wide marker data analyses to investigate the ancestry and genetic composition of the collected Danube Swabian samples.

resultsHaplotype-based analyses like identity by descent segment analysis show that the investigated Danube Swabians possess significant German and other West European ancestry, but their Hungarian ancestry is also prominent. Our results suggest that their main source of ancestry can be traced back to Western Europe, presumably to the region of Germany.

conclusionThis is the first analysis of Danube Swabian population samples based on genome-wide autosomal data. Our results establish the basis for conducting further comprehensive research on Danube Swabians and on other German ethnicities of the Carpathian basin, which can help reconstruct their origin, and identify their major archaic genomic patterns.

Indexed as

EthnicityGenetics, PopulationAgedEuropeGene FrequencyHumansHungaryAdmixtureEthnic groupGenome-wide dataHaplotypePopulation geneticsSwabians

Identifiers

PMID36624381
PMCPMC9830925

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