Evidence map›Paper›PMID 36624357›Full record

ArticleVeterinary research communications2023

First serological evidence of SARS-CoV-2 natural infection in small ruminants : Brief report.

Giovanna Fusco, Lorena Cardillo, Martina Levante, Sergio Brandi, Gerardo Picazio, Michele Napoletano, Alessandra Martucciello, Filomena Fiorito, Esterina De Carlo, Claudio de Martinis

Open access · hybridAbstract read
In one paragraph

Article in Veterinary research communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Giovanna FuscoDepartment of Animal Health, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Unit of Virology, Via Salute, 2, 80055, Portici, Naples, Italy.
Lorena CardilloDepartment of Animal Health, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Unit of Virology, Via Salute, 2, 80055, Portici, Naples, Italy. lorena.cardillo@izsmportici.it.
Martina LevanteDepartment of Animal Health, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Unit of Virology, Via Salute, 2, 80055, Portici, Naples, Italy.
Sergio BrandiDepartment of Animal Health, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Unit of Virology, Via Salute, 2, 80055, Portici, Naples, Italy.
Gerardo PicazioCEINGE Advanced Biotechnologies, Via G. Salvatore, 486, 80131, Naples, Italy. picazio@ceinge.unina.it.
Michele NapoletanoCaserta Section, Istituto Zooprofilattico Sperimentale del Mezzogiorno, 81100, Caserta, Italy.
Alessandra MartuccielloSalerno Section, Istituto Zooprofilattico Sperimentale del Mezzogiorno, 84131, Fuorni, Salerno, Italy.
Filomena FioritoDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137, Naples, Italy.
Esterina De CarloScientific Direction, Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055, Portici, Naples, Italy.
Claudio de MartinisDepartment of Animal Health, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Unit of Virology, Via Salute, 2, 80055, Portici, Naples, Italy.
Istituto Zooprofilattico Sperimentale del Mezzogiorno · ITCeinge Biotecnologie Avanzate (Italy) · ITUniversity of Naples Federico II · IT

Funding

Ministero della Salute CUP B29C20000080001
6 · The paper itself

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in late December 2019 and spread worldwide, quickly becoming a pandemic. This zoonotic coronavirus shows a broad host range, including wildlife and domestic animals. Small ruminants are shown to be susceptible to SARS-CoV-2 but, to date, no natural infection has been reported. Herein, we performed a survey for SARS-CoV-2 among sheep and goats in the Campania region of Italy using an indirect multispecies ELISA. Next, positive sera were submitted to virus serum neutralization for the quantification of specific neutralizing antibodies. Out of 612 sheep and goats, 23 were found ELISA positive (3.75%) and 1 of them showed 1:20 neutralizing antibodies titer. No significant difference was found between the two species, as well as between male and female, geographical location and age. Our findings demonstrate that natural infection can occur in flocks in a field situation. Moreover, low susceptibility to SARS-CoV-2 is reported for sheep and goats, nevertheless, the continuous mutations of this virus open new scenarios on viral host range and tropism, highlighting the importance of investigating animal species that could represent ongoing or future possible hosts.

Indexed as

COVID-19Goat DiseasesSheep DiseasesAnimalsAntibodies, NeutralizingAntibodies, ViralFemaleGoatsMaleRuminantsSARS-CoV-2SheepAntibodies, NeutralizingAntibodies, ViralGoatsHost rangeNatural infectionSARS-CoV-2SerologySheep

Identifiers

PMID36624357
PMCPMC9829525
OpenAlexW4313880479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.