Evidence map›Paper›PMID 36624089›Full record

ReviewTranslational psychiatry2023

Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression.

Bingqi Guo, Mengyao Zhang, Wensi Hao, Yuping Wang, Tingting Zhang, Chunyan Liu

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06940609 (Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation), which is not on this map. Cited by 209 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
209citing papers in PubMed, 10 pooled it
38.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06940609 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation (MANIFEST)

TypeinterventionalSponsorUniversity of New MexicoRan2025 to 2029Enrolled60ConditionsLong COVID, Long COVID Syndrome, Long COVID-19 Syndrome, PASCArmsaccelerated intermittent theta burst stimulation
3 · Its place in the literature

Who cites it

209 citing papers in PubMed, 10 syntheses or guidelines pooled it, 315 citations in OpenAlex.

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  11. Effect of transcutaneous vagus nerve stimulation in hemodialysis patients: A randomized controlled trial.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026
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  19. Palmitic Acid Amplifies Microglial Inflammatory Activation Involving C5aR1-Sensitive Inflammatory Signaling and JMJD3/H3K27me3-Related Epigenetic Changes.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
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  20. Review

149 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Bingqi GuoDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.ORCID 0000-0002-7399-2691
Mengyao ZhangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Wensi HaoDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Yuping WangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.ORCID 0000-0002-6482-9710
Tingting ZhangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. zhtingting129@163.com.ORCID 0000-0003-3687-3623
Chunyan LiuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. lcy_e_mail@163.com.ORCID 0000-0002-8063-6580
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mood disorders are associated with elevated inflammation, and the reduction of symptoms after multiple treatments is often accompanied by pro-inflammation restoration. A variety of neuromodulation techniques that regulate regional brain activities have been used to treat refractory mood disorders. However, their efficacy varies from person to person and lack reliable indicator. This review summarizes clinical and animal studies on inflammation in neural circuits related to anxiety and depression and the evidence that neuromodulation therapies regulate neuroinflammation in the treatment of neurological diseases. Neuromodulation therapies, including transcranial magnetic stimulation (TMS), transcranial electrical stimulation (TES), electroconvulsive therapy (ECT), photobiomodulation (PBM), transcranial ultrasound stimulation (TUS), deep brain stimulation (DBS), and vagus nerve stimulation (VNS), all have been reported to attenuate neuroinflammation and reduce the release of pro-inflammatory factors, which may be one of the reasons for mood improvement. This review provides a better understanding of the effective mechanism of neuromodulation therapies and indicates that inflammatory biomarkers may serve as a reference for the assessment of pathological conditions and treatment options in anxiety and depression.

Indexed as

Deep Brain StimulationElectroconvulsive TherapyAnimalsAnxietyDepressionNeuroinflammatory DiseasesTranscranial Magnetic Stimulation

Identifiers

PMID36624089
PMCPMC9829236
OpenAlexW4313888068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.