Evidence map›Paper›PMID 36623880›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2023

Relevance of Human Aldoketoreductases and Microbial

Abdul Basit, John K Amory, Vijaya Saradhi Mettu, Cindy Yanfei Li, Scott Heyward, Parth B Jariwala, Matthew R Redinbo, Bhagwat Prasad

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06312761 (Single-Dose Pharmacokinetics of Oral Testosterone Undecanoate With and Without Concomitant Inhibition of UGT2B17 With Oral Curcumin in Normal Men With Experimental Hypogonadism), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06312761 phase1 / phase2unknown statusnot on this mapstarted 2024, after this paper: background citation

Single-Dose Pharmacokinetics of Oral Testosterone Undecanoate With and Without Concomitant Inhibition of UGT2B17 With Oral Curcumin in Normal Men With Experimental Hypogonadism

TypeinterventionalSponsorUniversity of WashingtonRan2024 to 2025Enrolled10ConditionsHypogonadism, MaleArmsRelugolix 120Mg Tab, Curcumin, Testosterone Undecanoate 237 MG Oral Capsule
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. The urinary tract commensalApplied and environmental microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Abdul BasitDepartment of Pharmaceutical Sciences, Washington State University, Spokane, Washington (A.B., V.S.M., B.P.); Departments of Medicine (J.K.A.) and Pharmaceutics (C.Y.L.), University of Washington, Seattle, Washington; BioIVT Inc., Baltimore, Maryland (S.H.); and Departments of Chemistry, Biochemistry, and Microbiology and the Integrated Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (P.B.J., M.R.R.).
John K AmoryDepartment of Pharmaceutical Sciences, Washington State University, Spokane, Washington (A.B., V.S.M., B.P.); Departments of Medicine (J.K.A.) and Pharmaceutics (C.Y.L.), University of Washington, Seattle, Washington; BioIVT Inc., Baltimore, Maryland (S.H.); and Departments of Chemistry, Biochemistry, and Microbiology and the Integrated Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (P.B.J., M.R.R.).
Vijaya Saradhi MettuDepartment of Pharmaceutical Sciences, Washington State University, Spokane, Washington (A.B., V.S.M., B.P.); Departments of Medicine (J.K.A.) and Pharmaceutics (C.Y.L.), University of Washington, Seattle, Washington; BioIVT Inc., Baltimore, Maryland (S.H.); and Departments of Chemistry, Biochemistry, and Microbiology and the Integrated Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (P.B.J., M.R.R.).
Cindy Yanfei LiDepartment of Pharmaceutical Sciences, Washington State University, Spokane, Washington (A.B., V.S.M., B.P.); Departments of Medicine (J.K.A.) and Pharmaceutics (C.Y.L.), University of Washington, Seattle, Washington; BioIVT Inc., Baltimore, Maryland (S.H.); and Departments of Chemistry, Biochemistry, and Microbiology and the Integrated Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (P.B.J., M.R.R.).
Scott HeywardDepartment of Pharmaceutical Sciences, Washington State University, Spokane, Washington (A.B., V.S.M., B.P.); Departments of Medicine (J.K.A.) and Pharmaceutics (C.Y.L.), University of Washington, Seattle, Washington; BioIVT Inc., Baltimore, Maryland (S.H.); and Departments of Chemistry, Biochemistry, and Microbiology and the Integrated Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (P.B.J., M.R.R.).ORCID 0000-0001-7805-3522
Parth B JariwalaDepartment of Pharmaceutical Sciences, Washington State University, Spokane, Washington (A.B., V.S.M., B.P.); Departments of Medicine (J.K.A.) and Pharmaceutics (C.Y.L.), University of Washington, Seattle, Washington; BioIVT Inc., Baltimore, Maryland (S.H.); and Departments of Chemistry, Biochemistry, and Microbiology and the Integrated Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (P.B.J., M.R.R.).
Matthew R RedinboDepartment of Pharmaceutical Sciences, Washington State University, Spokane, Washington (A.B., V.S.M., B.P.); Departments of Medicine (J.K.A.) and Pharmaceutics (C.Y.L.), University of Washington, Seattle, Washington; BioIVT Inc., Baltimore, Maryland (S.H.); and Departments of Chemistry, Biochemistry, and Microbiology and the Integrated Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (P.B.J., M.R.R.).
Bhagwat PrasadDepartment of Pharmaceutical Sciences, Washington State University, Spokane, Washington (A.B., V.S.M., B.P.); Departments of Medicine (J.K.A.) and Pharmaceutics (C.Y.L.), University of Washington, Seattle, Washington; BioIVT Inc., Baltimore, Maryland (S.H.); and Departments of Chemistry, Biochemistry, and Microbiology and the Integrated Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (P.B.J., M.R.R.) bhagwat.prasad@wsu.edu.ORCID 0000-0002-9090-0912
University of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
PBPK prediction of ontogeny mediated alteration in hepatic drug eliminationR01HD081299 · NICHD · WASHINGTON STATE UNIVERSITY · PI PRASAD, BHAGWAT · 2015 to 2025
$4.6M
Structural Basis for Hormone and Neurotransmitter Processing by Gut Microbial EnzymesR01GM135218 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI REDINBO, MATTHEW R · 2019 to 2022
$1.5M
NCI NIH HHS P30 CA016086NICHD NIH HHS R01 HD081299NIGMS NIH HHS R01 GM135218
6 · The paper itself

Abstract

Testosterone exhibits high variability in pharmacokinetics and glucuronidation after oral administration. Although testosterone metabolism has been studied for decades, the impact of UGT2B17 gene deletion and the role of gut bacterial

Indexed as

DihydrotestosteroneGlucuronidaseGlucuronosyltransferaseHumansLiverMaleTestosteroneDihydrotestosteroneGlucuronidaseGlucuronosyltransferaseTestosterone

Identifiers

PMID36623880
PMCPMC10043941
OpenAlexW4313830682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.