Evidence map›Paper›PMID 36623713›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2023

Evaluation of drug carrier hepatotoxicity using primary cell culture models.

Güneş Kibar, Subhadeep Dutta, Kaushal Rege, O Berk Usta

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Güneş KibarCenter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Shriners Hospitals for Children, Boston, MA 02114, USA; Department of Materials Science and Engineering, Adana Alparslan Turkes Science and Technology University, Adana 01250, Turkey.
Subhadeep DuttaSchool of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.
Kaushal RegeSchool of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA; Chemical Engineering, School for Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ 85287, USA; Biological Design Graduate Program, School for Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ 85287, USA. Electronic address: rege@asu.edu.
O Berk UstaCenter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Shriners Hospitals for Children, Boston, MA 02114, USA. Electronic address: ousta@mgh.harvard.edu.
Arizona State University · US

Funding

Deep Supercooling of Red Blood Cells: Towards Practical Long Term StorageR01HL145031 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI USTA, OSMAN BERK, YARMUSH, MARTIN L · 2020 to 2023
$1.5M
Deep Supercooling of Liver Cells and 2D and 3D Tissue Constructs: Effect of AttachmentR21GM136002 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI USTA, OSMAN BERK · 2019 to 2020
$462k
Early Toxicity Detection Technologies via Exosomal Signatures in 3D Hepatic TissuesR21GM140656 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI USTA, OSMAN BERK · 2022 to 2023
$462k
DEVELOPMENT OF NOVEL AMINOGLYCOSIDE POLYMERS AND NANOPARTICLES FOR NUCLEIC ACID DELIVERY IN CHRONIC WOUNDSR41TR003247 · NCATS · SYNERGYAN, LLC · PI REGE, KAUSHAL · 2020 to 2020
$325k
NCATS NIH HHS R41 TR003247NHLBI NIH HHS R01 HL145031NIGMS NIH HHS R21 GM136002NIGMS NIH HHS R21 GM140656
6 · The paper itself

Abstract

This study aims to establish a primary rat hepatocyte culture model to evaluate dose-dependent hepatotoxic effects of drug carriers (lipopolymer nanoparticles; LPNs) temporal. Primary rat hepatocyte cell cultures were used to determine half-maximal Inhibition Concentrations (IC

Indexed as

Chemical and Drug Induced Liver InjuryDrug CarriersAlbuminsAnimalsCells, CulturedHepatocytesPrimary Cell CultureRatsUreaAlbuminsDrug CarriersUreaHepatotoxicityIn vitro cultureLipopolymer nanoparticle (LPN)NanotoxicityPrimary rat hepatocyte

Identifiers

PMID36623713
PMCPMC10492629
OpenAlexW4313627234

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.