Evidence map›Paper›PMID 36623419›Full record

Trial reportCortex; a journal devoted to the study of the nervous system and behavior2023

Effect of online tDCS to left somatomotor cortex on neuropsychiatric symptoms among older adults at risk for dementia.

Adam Turnbull, Mia Anthony, Duje Tadin, Anton P Porsteinsson, Kathi Heffner, Feng V Lin

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cortex; a journal devoted to the study of the nervous system and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Adam TurnbullCogT Lab, Department of Psychiatry and Behavioral Sciences, Stanford University, CA, USA; Departments of Brain and Cognitive Sciences, Neuroscience and Ophthalmology, University of Rochester, NY, USA. Electronic address: aturnbu2@stanford.edu.
Mia AnthonyCogT Lab, Department of Psychiatry and Behavioral Sciences, Stanford University, CA, USA; Departments of Brain and Cognitive Sciences, Neuroscience and Ophthalmology, University of Rochester, NY, USA.
Duje TadinDepartments of Brain and Cognitive Sciences, Neuroscience and Ophthalmology, University of Rochester, NY, USA.
Anton P PorsteinssonDepartments of Brain and Cognitive Sciences, Neuroscience and Ophthalmology, University of Rochester, NY, USA; Department of Psychiatry, University of Rochester Medical Center, NY, USA.
Kathi HeffnerDepartment of Psychiatry, University of Rochester Medical Center, NY, USA; Elaine Hubbard Center for Nursing Research on Aging, School of Nursing, University of Rochester Medical Center, NY, USA; Division of Geriatrics & Aging, Department of Medicine, University of Rochester Medical Center, NY, USA.
Feng V LinCogT Lab, Department of Psychiatry and Behavioral Sciences, Stanford University, CA, USA.
University of Rochester · USUniversity of Rochester Medical Center · USStanford University · US

Funding

U24 NEW Brain Aging Diversity SupplementU24AG072701 · NIA · UNIVERSITY OF ROCHESTER · PI CONWELL, YEATES, LIN, FENG VANKEE · 2021 to 2024
$2.6M
Validate a Shared Neural Circuit Underlying Multiple Neuropsychiatric SymptomsR21MH120734 · NIMH · UNIVERSITY OF ROCHESTER · PI HEFFNER, KATHI L, LIN, FENG VANKEE · 2019 to 2020
$419k
NIA NIH HHS U24 AG072701NIMH NIH HHS R21 MH120734
6 · The paper itself

Abstract

backgroundNeuropsychiatric symptoms (NPS) in mild cognitive impairment (MCI) cause distress to patients and caregivers, and accelerate progression to dementia. Transcranial direct current stimulation (tDCS) is a promising non-invasive treatment for NPS. OBJECTIVE/HYPOTHESIS: This pilot study assessed behavioral and neural effects of a 4-week anodal tDCS intervention targeting left sensorimotor cortex (LSMC: left precentral/postcentral gyri) during visual attention (compared to online sham tDCS), in 40 older adults (24 females, mean age = 71) with MCI.

methodsA phase 0 double-blinded randomized control trial was conducted. NPS (patient-reported mood symptoms plus a caregiver-reported questionnaire) and fMRI were measured at baseline and immediately post-intervention.

resultsGeneralized Estimating Equations found no significant group by time interactions for either NPS measure. However, there was evidence of decreased patient-reported NPS (Wald's χ

conclusionWe found tentative evidence that tDCS applied to LSMC during visual attention in older adults with MCI improved NPS via changes in LSMC activation and LSMC-amygdala rsFC, suggesting improved emotion regulation. Patient-reported NPS was more sensitive to these changes than caregiver-reports, and effects were strongest for left postcentral gyrus. Follow-up studies should perform precise mechanistic investigation and efficacy testing.

Indexed as

Cognitive DysfunctionDementiaTranscranial Direct Current StimulationAgedFemaleFollow-Up StudiesHumansPilot ProjectsBrain stimulationDementiaNon-pharmacological interventionstDCS

Identifiers

PMID36623419
PMCPMC9931675
OpenAlexW4313334354

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.