Evidence map›Paper›PMID 36622954›Full record

Trial reportExperimental physiology2023

Improved pulmonary function is associated with reduced inflammation after hybrid whole-body exercise training in persons with spinal cord injury.

Brandon A Yates, Robert Brown, Glen Picard, J Andrew Taylor

Open access · diamondAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Experimental physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Brandon A YatesCardiovascular Research Laboratory, Spaulding Rehabilitation Hospital, Cambridge, MA, USA.ORCID 0000-0003-2724-1376
Robert BrownPulmonary and Critical Care Medicine Unit and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Glen PicardCardiovascular Research Laboratory, Spaulding Rehabilitation Hospital, Cambridge, MA, USA.
J Andrew TaylorCardiovascular Research Laboratory, Spaulding Rehabilitation Hospital, Cambridge, MA, USA.
Harvard University · USIndiana University Health · USMassachusetts General Hospital · US

Funding

Hybrid-FES Exercise To Prevent Cardiovascular Declines In Acute Spinal Cord InjuryR01HL117037 · NHLBI · SPAULDING REHABILITATION HOSPITAL · PI TAYLOR, J ANDREW · 2013 to 2024
$4.9M
National Institute on Disability, Independent Living, and Rehabilitation Research - Spinal Cord Injury Model Systems Program 90S15021-01-00NHLBI NIH HHS 3R01HL117037-05S1NHLBI NIH HHS 5R01HL117037NHLBI NIH HHS R01 HL117037
6 · The paper itself

Abstract

NEW

findingsWhat is the central question of this study? Does 12 weeks of functional electrical stimulation (FES) rowing exercise training lead to suppressed systemic inflammation and an improvement in pulmonary function in persons with sub-acute spinal cord injury (SCI)? What is the main finding and its importance? Twelve weeks of FES rowing exercise improves pulmonary function and the magnitude of improvement is associated with reductions in inflammatory biomarkers. Thus, interventions targeting inflammation may lead to better pulmonary outcomes for person with sub-acute SCI. ABSTRACT: The current study was designed to test the hypotheses that (1) reducing systemic inflammation via a 12-week functional electrical stimulation rowing exercise training (FESRT) prescription results in augmented pulmonary function, and (2) the magnitude of improvement in pulmonary function is inversely associated with the magnitude of systemic inflammation suppression in persons with sub-acute (≤2 years) spinal cord injury (SCI). We conducted a retrospective analysis of a randomized controlled trial (NCT#02139436). Twenty-one participants were enrolled (standard of care (SOC; n = 9) or FESRT (n = 12)). The exercise prescription was three sessions/week at 70-85% of peak heart rate. A two-way analysis of covariance and regression analysis was used to assess group differences and associations between pulmonary function, log transformed high-sensitivity C-reactive protein (hsCRP

Indexed as

Electric Stimulation TherapySpinal Cord InjuriesC-Reactive ProteinExerciseExercise TherapyHumansInflammationRetrospective StudiesC-Reactive Proteinexercise physiologyparaplegiatetraplegia

Identifiers

PMID36622954
PMCPMC9991963
OpenAlexW4313839299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.