Evidence map›Paper›PMID 36622632›Full record

ArticleApplied biochemistry and biotechnology2023

Role of AIM2 Gene Knockdown Mechanism in Diabetic Cardiomyopathy: an In Vivo and Ex Vivo Study.

Qiang Li, Yonghui Liu, Jiatian Meng, Xiaoyu Li, Hui Li, Zili Meng

Abstract read
PubMed Publisher
In one paragraph

Article in Applied biochemistry and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. The Role of the AIM2 Gene in Obesity-Related Glucose and Lipid Metabolic Disorders: A Recent Update.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qiang Li *Department of Cardiovascular Surgery, Hebei Chest Hospital, Hebei Lung Cancer Research Center, Shijiazhuang, 050041, Hebei, China.
Yonghui Liu *Department of Cardiovascular Surgery, Hebei Chest Hospital, Hebei Lung Cancer Research Center, Shijiazhuang, 050041, Hebei, China.
Jiatian MengDepartment of Radiology, Hebei Chest Hospital, Hebei Lung Cancer Research Center, Shijiazhuang, 050041, Hebei, China.
Xiaoyu LiNursing Department of the Operating Theater, Hebei Chest Hospital, Hebei Lung Cancer Research Center, Shijiazhuang, 050041, Hebei, China.
Hui LiDepartment of Thoracic Surgery, Hebei Chest Hospital, Hebei Lung Cancer Research Center, Shijiazhuang, 050041, Hebei, China.
Zili MengDepartment of Cardiovascular Surgery, Hebei Chest Hospital, Hebei Lung Cancer Research Center, Shijiazhuang, 050041, Hebei, China. zilimeng0727@163.com.
Hospital of Hebei Province · CN

Funding

Department of Health of Hebei Province 1020140269Department of Health of Hebei Province 20130129Department of Health of Hebei Province 20150148
6 · The paper itself

Abstract

Chronic hyperglycemia induces reactive oxygen species that have an essential function in tissue injuries in cases of diabetic cardiomyopathy. The mechanism of the absent in melanoma 2 (AIM2)-associated inflammasome response in diabetic cardiomyopathy is unknown. Therefore, this study was performed to investigate the role of AIM2 and its molecular mechanisms. Diabetic rats received 1 × 10

Indexed as

Diabetes Mellitus, ExperimentalDiabetic CardiomyopathiesAnimalsCell Cycle ProteinsDNA-Binding ProteinsGene Knockdown TechniquesGlucoseMyocytes, CardiacRatsReactive Oxygen SpeciesAIM2 protein, ratCell Cycle ProteinsDNA-Binding ProteinsGlucoseReactive Oxygen SpeciesAbsent in melanoma 2CardiomyocytesDiabetes mellitusDiabetic cardiomyopathyReactive oxygen species

Identifiers

PMID36622632
OpenAlexW4313816702

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.