Evidence map›Paper›PMID 36622515›Full record

ReviewJournal of gastrointestinal cancer2023

The Role of Probiotics in Colorectal Cancer: A Review.

Shahad M Khaleel, Sadeel A Shanshal, Musab M Khalaf

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of gastrointestinal cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Probiotic intervention in colorectal cancer: the cytotoxic and apoptotic potential ofTurkish journal of biology = Turk biyoloji dergisi · 2026
    Article
  2. Molecular Mechanisms of Probiotic Action Against Gastrointestinal Cancers.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shahad M KhaleelDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Mosul, Mosul, Iraq.
Sadeel A ShanshalDepartment of Clinical Pharmacy, College of Pharmacy, University of Mosul, Mosul, Nineveh, Iraq. sadeelshanshal@uomosul.edu.iq.ORCID http://orcid.org/0000-0003-1248-4797
Musab M KhalafDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Mosul, Mosul, Iraq.
University of Mosul · IQ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGlobally, cancer is among the principal causes of death, and the incidence of colorectal cancer is increasing annually around the world, and it is currently ranked third most diagnosed cancer type. Despite the development in the treatment procedures for colorectal cancer including chemotherapy, surgery, immunotherapy and radiotherapy, the death rates from this cancer type are still elevated due to the adverse effects associated with treatment that may affect patients' quality of life.  Recently, the global interest in probiotics research has grown with significant positive results. 

methodsThis review discusses the role of probiotics in normal colorectal physiology and cancer.

resultsProbiotics will become an essential part in the prevention and management of colorectal cancer in the near future as they are expected to provide a solution to the problems associated with cancer treatment. Probiotics' properties open the way for multiple effective uses in colorectal cancer prevention strategies. Additionally, probiotics can reduce the problems associated with chemotherapy and surgery when used synergistically. Probiotics can also increase the efficacy of chemotherapeutic medications. Targeted drug delivery and TRAIL collaboration techniques are other effective and promising methods that involve probiotics.

conclusionsProbiotics have properties that make them useful in the management and prevention of colorectal cancer and can provide new avenue to reduce the occurrence of this malignancy and enhance the patients' quality of life.

Indexed as

Colorectal NeoplasmsProbioticsHumansQuality of LifeColorectal cancerDysbiosisPrebioticsProbiotics

Identifiers

PMID36622515
OpenAlexW4313814655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.