ArticlePediatric surgery international2023
Prognostic factors of postoperative Hirschsprung-associated enterocolitis: a cohort study.
Article in Pediatric surgery international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 18 citations in OpenAlex.
- Preoperative nutritional support in children with Hirschsprung disease: a prospective multicenter open-label randomized controlled trial.Nature communications · 2025Trial
- Comparison of Postoperative Outcomes of Duhamel and Transanal Endorectal Pull-Through in Hirschsprung Disease: A Propensity Score Study.Pediatric reports · 2026Article
- Longitudinal analysis of gut microbiota dysbiosis and bacterial signatures predictive of postoperative enterocolitis in children with Hirschsprung disease.Clinical and experimental pediatrics · 2026Article
- Research progress on continuous nursing care for children after radical surgery for Hirschsprung's disease.Frontiers in public health · 2026Review
- Perioperative outcomes of neonatal versus delayed surgery for Hirschsprung disease: a nationwide retrospective cohort study in Japan.Pediatric surgery international · 2025Article
- Risk factors and nomogram model for short-term postoperative complications in patients with hirschsprung disease.BMC medical informatics and decision making · 2025Article
- Postoperative Hirschsprung's associated enterocolitis (HAEC): transition zone as putative histopathological predictive factor.Journal of clinical pathology · 2025Article
- Mesenchymal Stem Cell Derived Exosomes Alleviates Hirschsprung-Associated Enterocolitis by Inhibiting AKT Phosphorylation in Macrophages Through miR-223.Stem cells international · 2025Article
- Development of a nomogram for predicting postoperative Hirschsprung-associated enterocolitis.Frontiers in pediatrics · 2025Article
- Prevalence and Factors associated with Bowel Dysfunctions after Pull-Through Surgery in Children Diagnosed with Hirschsprung Disease.Pediatric gastroenterology, hepatology & nutrition · 2024Article
- Angiopoietin-1 attenuates lipopolysaccharide-induced endotoxemia in a Hirschsprung's disease murine model by improving intestinal vascular integrity: implications for treating postoperative Hirschsprung-associated enterocolitis.Pediatric surgery international · 2024Article
- Surgical and clinical determinants of postoperative Hirschsprung-associated enterocolitis: Multivariate analysis in a large cohort.Pediatric discovery · 2024Article
- Clinical characteristics and influence of postoperative Hirschsprung-associated enterocolitis: retrospective study at a tertiary children's hospital.Pediatric surgery international · 2024Article
- Risk factors and simple scoring system for predicting postoperative nutritional status of Hirschsprung's disease.Frontiers in nutrition · 2024Article
- Hirschsprung disease.Nature reviews. Disease primers · 2023Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo identify prognostic factors of postoperative Hirschsprung-associated enterocolitis (HAEC).
methodA retrospective cohort study of Hirschsprung patients between 2006 and 2021 was conducted. Patients with anorectal malformation and non-definitive surgery were excluded. Associated factors for postoperative HAEC were reported with hazard ratio (HR) and 95% confidence interval (CI).
resultsForty-nine patients were excluded due to concurrent anorectal malformation and incomplete data. Of 274 patients, 75 patients (27.4%) had at least one episode of postoperative HAEC. There were 28 patients (37.3%) who had multi-episodes of HAEC. The total episodes of post-operative HAEC in this study were 121 episodes (36.8%). In multivariable survival analysis, significant factors associated with postoperative HAEC were the aganglionic level above sigmoid colon (HR = 3.47, p = 0.023, 95% CI 1.19-10.09), and total colonic aganglionosis (HR = 14.83, p = 0.004, 95% CI 2.33-94.40). The patients who experienced clinical enterocolitis before 2 weeks after surgery significantly developed more postoperative HAEC (HR = 5.32, p = 0.038, % CI 1.09-25.92). The incidence of postoperative HAEC was increase in patients with postoperative obstructive symptoms (48.0%). One patient died due to severe sepsis from postoperative HAEC, while three others required intensive care.
conclusionsThe long involvement of aganglionic segment and early postoperative HAEC was significantly associated with postoperative HAEC. Frequent follow-up, parental education, and early treatment are recommended in these individuals, particularly in the first year after surgery.
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