Evidence map›Paper›PMID 36622408›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2023

The effect of palm oil-derived tocotrienol-rich fraction in preserving normal retinal vascular diameter in streptozotocin-induced diabetic rats.

Nurliyana Ain Abdul Ghani, Nurul Alimah Abdul Nasir, Lidawani Lambuk, Muhammad Zulfiqah Sadikan, Renu Agarwal, Norlina Ramli

Abstract read
PubMed Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Nurliyana Ain Abdul GhaniDepartment of Ophthalmology, Faculty of Medicine, University Malaya Eye Research Centre, University of Malaya, Kuala Lumpur, Malaysia.
Nurul Alimah Abdul NasirCentre for Neuroscience Research, Faculty of Medicine, Universiti Teknologi MARA, Selangor, Malaysia. nurulalimah@uitm.edu.my.ORCID http://orcid.org/0000-0002-4285-7059
Lidawani LambukCentre for Neuroscience Research, Faculty of Medicine, Universiti Teknologi MARA, Selangor, Malaysia.
Muhammad Zulfiqah SadikanCentre for Neuroscience Research, Faculty of Medicine, Universiti Teknologi MARA, Selangor, Malaysia.
Renu AgarwalSchool of Medicine, International Medical University, Kuala Lumpur, Malaysia.
Norlina RamliDepartment of Ophthalmology, Faculty of Medicine, University Malaya Eye Research Centre, University of Malaya, Kuala Lumpur, Malaysia.
Universiti Teknologi MARA · MYUniversity of Malaya · MYIMU University · MYManipal University College Malaysia · MY

Funding

Fundamental Research Grant Scheme by Ministry of Higher Education 600-IRMI/FRGS 5/3 (101/2019
6 · The paper itself

Abstract

purposeAngiogenesis in diabetic retinopathy (DR) is associated with increased retinal expression of angiopoietin-2 (Ang-2) and protein kinase C (PKC). Tocotrienol-rich fraction (TRF) has been shown to reduce the expression vascular endothelial growth factor (VEGF) in several experimental models. However, its effect against other angiogenic markers such as Ang-2 and PKC in rat model of diabetes remains unknown. Therefore, we investigated the effect of TRF on the retinal vascular changes and Ang-2 and PKC expressions in rats with streptozotocin (STZ)-induced DR.

methodsSprague-Dawley rats were divided into normal control rats (N) which received vehicle, and diabetic rats which either received vehicle (DV) or 100 mg/kg of TRF (DT). Diabetes was induced with intraperitoneal injection of STZ (60 mg/kg body weight). Treatments were given orally, once daily, for 12 weeks after confirmation of hyperglycaemia. Fundus photographs were captured at baseline, 6- and 12-week post-STZ injection and average diameter of retinal veins and arteries were measured. At 12-week post-STZ injection, rats were euthanised, and retinae were collected for measurement of Ang-2 and PKC gene and protein expressions.

resultsRetinal venous and arterial diameters were significantly greater in DV compared to DT at week 12 post-STZ injection (p < 0.001 and < 0.05, respectively). The vessel diameter measurements in DT were comparable to N and this effect of TRF was associated with significantly lower Ang-2 and PKC gene and protein expressions compared to DV.

conclusionOral TRF reduces the expression of retinal angiogenic markers and preserves the retinal vascular diameter of rats with STZ-induced DR.

Indexed as

Diabetes Mellitus, ExperimentalDiabetic RetinopathyTocotrienolsAnimalsPalm OilProtein Kinase CRatsRats, Sprague-DawleyRetinal VesselsStreptozocinVascular Endothelial Growth Factor APalm OilProtein Kinase CStreptozocinTocotrienolsVascular Endothelial Growth Factor AAngiopoietin-2Diabetic retinopathyProtein kinase CStreptozotocinTocotrienol-rich fraction

Identifiers

PMID36622408
OpenAlexW4313824447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.