Evidence map›Paper›PMID 36622282›Full record

ArticleAging2023

Alcohol consumption and epigenetic age acceleration in young adults.

Drew R Nannini, Brian T Joyce, Yinan Zheng, Tao Gao, Jun Wang, Lei Liu, David R Jacobs, Pamela J Schreiner, Chunyu Liu, Qi Dai and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

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  19. PTSD and Alcohol Use Disorders Predict the Pace of Cellular Aging.Journal of mood and anxiety disorders · 2023
    Article
  20. Association between the epigenetic lifespan predictor GrimAge and history of suicide attempt in bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Drew R NanniniDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Brian T JoyceDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Yinan ZhengDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Tao GaoDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Jun WangDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Lei LiuDivision of Biostatistics, Washington University, St. Louis, MO 63110, USA.
David R JacobsDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.
Pamela J SchreinerDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.
Chunyu LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
Qi DaiDepartment of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Steve HorvathDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Ake T LuDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Kristine YaffeUniversity of California at San Francisco School of Medicine, San Francisco, CA 94143, USA.
Philip GreenlandDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Donald M Lloyd-JonesDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Lifang HouDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Northwestern University · USUniversity of California, Los Angeles · USUniversity of Minnesota · USBoston University · USUniversity of California, San Francisco · USVanderbilt University Medical Center · USWashington University in St. Louis · US

Funding

Blood mitochondrial DNA biomarkers of midlife cognitive decline and adverse brain imaging changes - A longitudinal investigation in the CARDIA population‐based cohort studyR01AG069120 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HOU, LIFANG, YAFFE, KRISTINE · 2020 to 2024
$4.0M
Innovative Analytical Methods for DNA Methylation AgeR21AG068955 · NIA · WASHINGTON UNIVERSITY · PI LIU, LEI, ZHENG, YINAN · 2021 to 2022
$448k
High Dimensional Mediation Analysis for DNA Methylation Markers Mediating Cardiovascular Health Metrics and Cardiovascular DiseasesR21AG063370 · NIA · WASHINGTON UNIVERSITY · PI HOU, LIFANG, LIU, LEI · 2019 to 2020
$447k
NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INIA NIH HHS R01 AG069120NIA NIH HHS R21 AG063370NIA NIH HHS R21 AG068955
6 · The paper itself

Abstract

Alcohol is a widely consumed substance in the United States, however its effect on aging remains understudied. In this study of young adults, we examined whether cumulative alcohol consumption, i.e., alcohol years of beer, liquor, wine, and total alcohol, and recent binge drinking, were associated with four measures of age-related epigenetic changes via blood DNA methylation. A random subset of study participants in the Coronary Artery Risk Development in Young Adults Study underwent DNA methylation profiling using the Illumina MethylationEPIC Beadchip. Participants with alcohol consumption and methylation data at examination years 15 (

Indexed as

Binge DrinkingWineAgedAlcohol DrinkingAlcoholic BeveragesBeerEpigenomicsHumansUnited Statesalcoholbinge drinkingDNA methylationepigenetic agelifetime alcohol consumption

Identifiers

PMID36622282
PMCPMC9925681
OpenAlexW4313554446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.