Evidence map›Paper›PMID 36622252›Full record

Trial reportmSphere2023

Influence of Hormonal Contraceptive Use and HIV on Cervicovaginal Cytokines and Microbiota in Malawi.

Lisa B Haddad, Jennifer H Tang, Nicole L Davis, Athena P Kourtis, Lameck Chinula, Albans Msika, Gerald Tegha, Mina C Hosseinipour, Julie A E Nelson, Marcia M Hobbs and 3 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in mSphere, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Influence of Different Litter Regimens on Ceca Microbiota Profiles inAnimals : an open access journal from MDPI · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Lisa B HaddadCenter for Biomedical Research, Population Council, New York, New York, USA.ORCID 0000-0002-7631-6760
Jennifer H TangUniversity of North Carolina at Chapel Hill, Department of Obstetrics & Gynecology, Chapel Hill, North Carolina, USA.
Nicole L DavisU.S. Centers for Disease Control and Prevention, Division of HIV Prevention, Atlanta, Georgia, USA.
Athena P KourtisU.S. Centers for Disease Control and Prevention, Division of HIV Prevention, Atlanta, Georgia, USA.
Lameck ChinulaUniversity of North Carolina at Chapel Hill, Department of Obstetrics & Gynecology, Chapel Hill, North Carolina, USA.
Albans MsikaUNC Project-Malawi, Kamuzu Central Hospital, Lilongwe, Malawi.
Gerald TeghaUNC Project-Malawi, Kamuzu Central Hospital, Lilongwe, Malawi.
Mina C HosseinipourUNC Project-Malawi, Kamuzu Central Hospital, Lilongwe, Malawi.
Julie A E NelsonUniversity of North Carolina at Chapel Hill, Department of Microbiology and Immunology, Chapel Hill, North Carolina, USA.
Marcia M HobbsUniversity of North Carolina at Chapel Hill, Department of Microbiology and Immunology, Chapel Hill, North Carolina, USA.
Pawel GajerInstitute for Genome Sciences, University of Maryland School of Medicine, Health Sciences Facility III, Baltimore, Maryland, USA.
Jacques RavelInstitute for Genome Sciences, University of Maryland School of Medicine, Health Sciences Facility III, Baltimore, Maryland, USA.ORCID 0000-0002-0851-2233
Kristina De ParisUniversity of North Carolina at Chapel Hill, Department of Microbiology and Immunology, Chapel Hill, North Carolina, USA.ORCID 0000-0001-5199-3004
University of North Carolina at Chapel Hill · USCenters for Disease Control and Prevention · USKamuzu Central Hospital · MWUniversity of Maryland, Baltimore · USPopulation Council · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
UNC CENTER FOR HEALTH PROMOTION AND DISEASE PREVENTIONU48DP001944 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AMMERMAN, ALICE S · 2009 to 2013
$15.1M
Evaluation of the immunologic and genital tract changes among Malawian women K01TW009657 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TANG, JENNIFER · 2013 to 2016
$565k
Bill and Melinda Gates Foundation (GF) OPP1090837FIC NIH HHS K01 TW009657HHS | Centers for Disease Control and Prevention (CDC) 200-2015-M-63021HHS | Centers for Disease Control and Prevention (CDC) U48DP00194HHS | National Institutes of Health (NIH) 1K01-TW009657-01HHS | NIH | Office of Extramural Research, National Institutes of Health (OER) P30-AI50410NCCDPHP CDC HHS U48 DP001944NCI NIH HHS P30 CA016086NIAID NIH HHS P30 AI050410
6 · The paper itself

Abstract

Important questions remain on how hormonal contraceptives alter the local immune environment and the microbiota in the female genital tract and how such effects may impact susceptibility to HIV infection. We leveraged samples from a previously conducted clinical trial of Malawian women with (

Indexed as

Contraceptive Agents, HormonalHIV InfectionsMicrobiotaContraceptive AgentsCytokinesFemaleHumansLevonorgestrelMalawiMedroxyprogesterone AcetateProgestinsRNA, Ribosomal, 16SContraceptive AgentsContraceptive Agents, HormonalCytokinesLevonorgestrelMedroxyprogesterone AcetateProgestinsRNA, Ribosomal, 16Scontraceptioncytokinesdepot medroxyprogesterone acetate injectableHIVinflammationlevonorgestrel implantmicrobiomeprogestinprogestin contraception

Identifiers

PMID36622252
PMCPMC9942570
OpenAlexW4313877403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.