Evidence map›Paper›PMID 36621597›Full record

ArticleContemporary clinical trials2023

Protocol for a 4-arm randomized controlled trial testing remotely delivered exercise-only, diet-only, and exercise + diet interventions among men with prostate cancer treated with radical prostatectomy (Prostate 8-II).

Erin L Van Blarigan, June M Chan, Ada Sanchez, Li Zhang, Kerri Winters-Stone, Vivian Liu, Greta Macaire, Neil Panchal, Rebecca E Graff, Imelda Tenggara and 5 more

Registry-linked trialOpen access · greenAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06451120 (Study of Platelet Rich Plasma), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06451120 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Study of Platelet Rich Plasma (PRP) Injections With Symptomatic Knee Osteoarthritis for Biomarker Exploration in Young and Old Human Subjects

TypeinterventionalSponsorUniversity of California, San FranciscoRan2024 to 2027Enrolled60ConditionsOsteoarthritis, Articular Cartilage, Musculoskeletal DisordersArmsPlatelet-Rich Plasma (PRP) Injections, Centrifuge, Control saline injection
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Erin L Van BlariganDepartment of Urology, University of California, San Francisco, (UCSF), San Francisco, CA, United States of America; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States of America; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States of America.
June M ChanDepartment of Urology, University of California, San Francisco, (UCSF), San Francisco, CA, United States of America; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States of America; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States of America.
Ada SanchezDepartment of Urology, University of California, San Francisco, (UCSF), San Francisco, CA, United States of America.
Li ZhangDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States of America; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States of America; Department of Medicine, University of California, San Francisco, San Francisco, CA, United States of America.
Kerri Winters-StoneDivision of Oncological Sciences, School of Medicine, Oregon Health & Sciences University, Portland, OR, United States of America.
Vivian LiuDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States of America.
Greta MacaireUCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States of America.
Neil PanchalUCSF Human Performance Center, San Francisco, CA, United States of America.
Rebecca E GraffDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States of America.
Imelda TenggaraDepartment of Urology, University of California, San Francisco, (UCSF), San Francisco, CA, United States of America.
Anthony LukeUCSF Human Performance Center, San Francisco, CA, United States of America; Department of Orthopedic Surgery, University of California, San Francisco, San Francisco, CA, United States of America.
Jeffry P SimkoDepartment of Urology, University of California, San Francisco, (UCSF), San Francisco, CA, United States of America; Department of Pathology, University of California, San Francisco, San Francisco, CA, United States of America.
Matthew R CooperbergDepartment of Urology, University of California, San Francisco, (UCSF), San Francisco, CA, United States of America; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States of America; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States of America.
Peter R CarrollDepartment of Urology, University of California, San Francisco, (UCSF), San Francisco, CA, United States of America; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States of America.
Stacey A KenfieldDepartment of Urology, University of California, San Francisco, (UCSF), San Francisco, CA, United States of America; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States of America; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States of America. Electronic address: stacey.kenfield@ucsf.edu.
University of California, San Francisco · USUCSF Helen Diller Family Comprehensive Cancer Center · US

Funding

Impact of Web-Based Lifestyle Interventions on Prostate Cancer PrognosisR01CA207749 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KENFIELD, STACEY · 2016 to 2021
$3.3M
NCI NIH HHS R01 CA207749
6 · The paper itself

Abstract

backgroundNutrition and physical activity are associated with prostate cancer recurrence and mortality. Few randomized controlled trials (RCT) have examined the effects of long-term exercise and diet changes on prostate cancer clinical, biological, and patient-reported outcomes.

methodsProstate 8-II is a 4-arm RCT among 200 men with prostate cancer who chose radical prostatectomy (RP) as their primary treatment. Men are enrolled prior to RP and randomized to exercise-only, diet-only, exercise + diet, or usual care (50/arm). Participants begin their assigned intervention 0-5 weeks prior to RP and continue for 24-months following surgery. The 3 active intervention arms receive access to a web-portal and text messages, coaching calls, and other intervention resources (e.g., heart rate sensor and resistance bands and/or recipe booklet). Weekly exercise goals for the exercise intervention groups are 150 min moderate or 75 min vigorous aerobic exercise, 2 strength sessions, and 2 flexibility sessions. Diet intervention groups work with a dietitian to customize their goals (e.g., increase cruciferous vegetables, cooked tomatoes, healthy fats, fish; limit processed meats, whole milk). The primary endpoint is biochemical recurrence. Secondary endpoints include change in tumor biomarkers from biopsy to RP as well as patient-reported outcomes (e.g., quality-of-life), blood and urine biomarkers, and anthropometry at 0, 6, 12, and 24 months.

conclusionThis 4-arm RCT will examine the impact of change in exercise and diet (alone or in combination) on prostate cancer recurrence, biology, and quality-of-life.

Indexed as

ProstateProstatic NeoplasmsDietExerciseHumansMaleNeoplasm Recurrence, LocalProstatectomyRandomized Controlled Trials as TopicBehavioral interventionCancer survivorshipNutritionPhysical activityProstate-specific antigen (PSA) levelsQuality-of-life

Identifiers

PMID36621597
PMCPMC12952565
OpenAlexW4313561506

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.