Evidence map›Paper›PMID 36621469›Full record

ArticleNeurotoxicology2023

The association of auditory function measures with low-level methylmercury from oceanic fish consumption and mercury vapor from amalgam: The Seychelles Child Development Study Nutrition 1 Cohort.

Mark S Orlando, Tanzy Love, Donald Harrington, Adam C Dziorny, Conrad F Shamlaye, Gene E Watson, Edwin van Wijngaarden, Philip W Davidson, Gary J Myers

Open access · greenAbstract read
In one paragraph

Article in Neurotoxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Mark S OrlandoDepartment of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA. Electronic address: mark_orlando@urmc.rochester.edu.
Tanzy LoveDepartment of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA.
Donald HarringtonDepartment of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA.
Adam C DziornyDepartment of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA; Department of Biomedical Engineering, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA.
Conrad F ShamlayeMinistry of Health, Republic of Seychelles.
Gene E WatsonEastman Institute for Oral Health, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA; Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA; Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA.
Edwin van WijngaardenDepartment of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA; Eastman Institute for Oral Health, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA; Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA; Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA; Department of Community Health and Prevention, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA.
Philip W DavidsonDepartment of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA; Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA; Department of Psychiatry, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA.
Gary J MyersDepartment of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA; Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA; Department of Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA.
University of Rochester · USMinistry of Health · SC

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Martha Susiarjo · 1985 to 2026
$42.8M
TOXICITY OF METHYL MERCURY IN A FISH EATING POPULATIONR01ES010219 · NIEHS · UNIVERSITY OF ROCHESTER · PI VAN WIJNGAARDEN, EDWIN · 2000 to 2019
$11.8M
TRAINING IN ENVIRONMENTAL HEALTH SCIENCES BIOSTATISTICST32ES007271 · NIEHS · UNIVERSITY OF ROCHESTER · PI Sally W Thurston · 1992 to 2026
$3.9M
Mercury Vapor from Amalgam and Methylmercury Co-Exposure on NeurodevelopmentR01ES015578 · NIEHS · UNIVERSITY OF ROCHESTER · PI WATSON, GENE E · 2007 to 2011
$2.9M
Leveraging Investments in the Seychelles Child Development Study to Enable Novel Investigations of Long-Term MeHg Exposure, Toxicity Mechanisms, and Health across the Life CourseR24ES029466 · NIEHS · UNIVERSITY OF ROCHESTER · PI VAN WIJNGAARDEN, EDWIN · 2020 to 2024
$1.6M
NIEHS NIH HHS P30 ES001247NIEHS NIH HHS R01 ES010219NIEHS NIH HHS R01 ES015578NIEHS NIH HHS R24 ES029466NIEHS NIH HHS T32 ES007271
6 · The paper itself

Abstract

backgroundSome authors have reported that low-level exposure to methylmercury (MeHg) adversely impacts measures of auditory function. These reports, however, are not consistent in their findings. Consequently, we examined auditory function in a population exposed to low-level methylmercury (MeHg) exposure from fish consumption and to mercury vapor (Hg

designWe administered an audiometry test battery to 246 participants from the Seychelles Child Development Study (SCDS) Nutrition Cohort 1 (NC1) at 9 years of age. The test battery included standard pure-tone audiometry, tympanometry, Auditory Brainstem Responses (ABR) and Distortion Product and Click Evoked Otoacoustic Emissions (DPOAE and CEOAE) testing. We measured prenatal MeHg exposure in maternal hair and postnatal MeHg in children's hair. We approximated prenatal Hg

resultsHg exposures were similar for both sexes. Seven of the 210 evaluable participants examined had either a mild (5) or moderate (2) hearing loss. Four had a mild monaural hearing loss and 3 had either a mild (1) or moderate (2) bilateral hearing loss. No participant had greater than a moderate hearing loss in either ear. Hg exposures were higher in participants with either a mild or moderate hearing loss, but these differences were not statistically significant. Among the 210 with complete data, neither prenatal nor postnatal MeHg nor Hg

conclusionOverall, these data do not present a clear and consistent pattern to suggest that the auditory system is negatively affected by low-level methylmercury exposure due to dietary consumption of oceanic fish or mercury vapor exposure from dental amalgams.

Indexed as

Hearing LossMercuryMethylmercury CompoundsPrenatal Exposure Delayed EffectsAnimalsChild DevelopmentDental AmalgamFemaleHearingHumansMalePregnancySeychellesDental AmalgamMercuryMethylmercury CompoundsAuditory brainstem responsesDental amalgamFish consumptionMercury vaporMethylmercuryOtoacoustic emissionSeychelles child development study

Identifiers

PMID36621469
PMCPMC9998349
OpenAlexW4313559531

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.