Evidence map›Paper›PMID 36621080›Full record

ArticlePhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)2023

Cobalt compensator-based IMRT device: A treatment planning study of head and neck cases.

Bishwambhar Sengupta, Kyuhak Oh, Patricia Sponseller, Peter Zaki, Boryana Eastman, Tru-Khang T Dinh, Carlos E Cardenas, Laurence E Court, Upendra Parvathaneni, Eric Ford

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Bishwambhar SenguptaDepartment of Radiation Oncology, University of Washington, Seattle, USA.
Kyuhak OhDepartment of Radiation Oncology, University of Washington, Seattle, USA; M.D. Anderson Cancer Center, Houston, USA.
Patricia SponsellerDepartment of Radiation Oncology, University of Washington, Seattle, USA.
Peter ZakiDepartment of Radiation Oncology, University of Washington, Seattle, USA.
Boryana EastmanDepartment of Radiation Oncology, University of Washington, Seattle, USA.
Tru-Khang T DinhDepartment of Radiation Oncology, University of Washington, Seattle, USA.
Carlos E CardenasDepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.
Laurence E CourtM.D. Anderson Cancer Center, Houston, USA.
Upendra ParvathaneniDepartment of Radiation Oncology, University of Washington, Seattle, USA.
Eric FordDepartment of Radiation Oncology, University of Washington, Seattle, USA. Electronic address: eford@uw.edu.
University of Washington · USThe University of Texas MD Anderson Cancer Center · USUniversity of Alabama at Birmingham · US

Funding

A cost-effective radiation treatment delivery system for the low- and middle-income countriesUH3CA211310 · NCI · UNIVERSITY OF WASHINGTON · PI FORD, ERIC C · 2019 to 2022
$2.6M
NCI NIH HHS UH3 CA211310
6 · The paper itself

Abstract

purposeOur goal is to develop a novel cobalt-compensator-based IMRT device for low- and middle-income countries that is reliable and cost-effective while delivering treatment plans of equal quality to those from linac-MLC devices. The present study examines the quality of treatment plans using this device.

methodsA commercial treatment planning system (TPS; RayStation v.8B) was commissioned for this device using Monte Carlo simulations from the Geant4 toolkit. Patient-specific compensators were created as regions-of-interest. Thirty clinical head & neck cases were planned and compared to clinical plans with a 6MV linac using IMRT. The mock head and neck plan from TG-119 was used for further validation.

resultsPTV objectives were achieved in all 30 plans with PTV V95% >95 %. OAR sparing was similar to clinical plans. There were 14 cases where OAR dose limits exceeded the recommended QUANTEC limits in the clinical plan in order to achieve target coverage. OAR sparing was better in the cobalt compensator plan in 8 cases and worse in 3 cases, in the latter cases exceeding the clinical plan doses by an average of 8.22 % (0.0 %-13.5 %). Average field-by-field gamma pass-rate were 93.7 % (2 %/2mm). Estimated treatment times using the Co-60 compensator device were 1 min 27 s vs 1 min 2 s for the clinical system.

conclusionThis system is the first of its kind to allow for IMRT with a Co-60 device. Data here suggests that the delivery meets plan quality criteria while maintaining short treatment times which may offer a sustainable and cost-low option for IMRT on the global scale.

Indexed as

Head and Neck NeoplasmsRadiotherapy, Intensity-ModulatedCobaltCobalt RadioisotopesHumansRadiotherapy DosageRadiotherapy Planning, Computer-AssistedCobaltCobalt-60Cobalt RadioisotopesCobalt-60CompensatorGlobal oncologyHead and neckIMRT

Identifiers

PMID36621080
PMCPMC10468209
OpenAlexW4313621243

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.