ArticleEuropean journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society2023
Pediatric recurrent acute necrotizing encephalomyelitis, RANBP2 genotype and Sars-CoV-2 infection: Diagnosis, pathogenesis and targeted treatments from a case study.
Article in European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Defining the Clinicoradiologic Syndrome of SARS-CoV-2 Acute Necrotizing Encephalopathy: A Systematic Review and 3 New Pediatric CasesNeurology(R) neuroimmunology & neuroinflammation · 2024Pooled it
- Acute necrotizing encephalopathy associated with COVID-19: case series and systematic review.Journal of neurology · 2023Pooled it
- A nomogram model for early recognition of acute necrotizing encephalopathy: a retrospective study.Translational pediatrics · 2026Article
- Acute necrotizing encephalopathy associated with COVID-19 in a pediatric patient and a systematic review.Journal of human immunity · 2026Article
- Influenza Virus-Associated Acute Necrotizing Encephalopathy in Two Young Children: Case Report.Reports (MDPI) · 2024Article
- Recurrent infection triggered encephalopathy syndrome in a pediatric patient withPediatric investigation · 2023Article
- Exploring the molecular and clinical spectrum of COVID-19-related acute necrotizing encephalopathy in three pediatric cases.Journal of human genetics · 2023Article
- Letter to the Editor in response to Dr. Josef Finsterer et al. "Intense work-up is required for pediatric COVID-related acute necrotizing encephalopathy with RANBP2 variants".European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2023Article
- Intense work-up is required for pediatric COVID-related acute necrotizing encephalopathy with RANBP2 variants.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2023Article
- The youngest infant with COVID-19-associated necrotizing encephalitis in Asia: A case report.SAGE open medical case reports · 2023Article
- Acute necrotizing encephalopathy in children with COVID-19: a retrospective study of 12 cases.Frontiers in neurology · 2023Article
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10 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Acute necrotizing encephalopathy (ANE) is a rare disease not yet described in children with Covid-19. RANBP2 gene variations are implicated in recurrences in the genetic form of ANE, the so called ANE1. We report the first case of pediatric ANE1 following Sars-CoV-2 infection. She had a first episode at 2 years of age following influenza type A with full recovery, many other respiratory and non-respiratory febrile viral infections without recurrences and a severe recurrence following Sars-CoV-2 infection, suggesting a potentiation effect on cytokine cascade. Her MRI showed the typical pattern of injury resembling that of mitochondrial disorders, and supported the role of RANBP2 in mitochondrial homeostasis. This case rises attention on diagnostic challenges and offers several interesting tips for discussion about new perspectives in pathogenesis and targeted treatments.
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