ArticleFrontiers in aging neuroscience2022
Cognitive parameters can predict change of walking performance in advanced Parkinson's disease - Chances and limits of early rehabilitation.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Potential Effects of Computer-Based Cognitive Training on Postural Stability and Locomotion in Parkinson's Disease Patients: A Randomized Controlled Trial.Annals of rehabilitation medicine · 2025Article
- User groups of inpatient multidisciplinary therapies for Parkinson's disease in Germany: a bicenter prospective observational study.Neurological research and practice · 2025Article
- Research progress of multimodal biomarkers in the early diagnosis of mild cognitive impairment in Parkinson's disease.Frontiers in neurology · 2025Review
- Predicting executive functioning from walking features in Parkinson's disease using machine learning.Scientific reports · 2024Article
- Trend change analysis of postural balance in Parkinson's disease discriminates between medication state.Journal of neuroengineering and rehabilitation · 2024Article
- A Comparative Analysis of Symmetry Indices for Spatiotemporal Gait Features in Early Parkinson's Disease.Neurology international · 2023Article
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Authors and funding
11 authors at 2 institutions in 1 country.
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Abstract
Introduction: Links between cognition and walking performance in patients with Parkinson's disease (PD), which both decline with disease progression, are well known. There is lack of knowledge regarding the predictive value of cognition for changes in walking performance after individualized therapy. The aim of this study is to identify relevant predictive cognitive and affective parameters, measurable in daily clinical routines, for change in quantitative walking performance after early geriatric rehabilitation. Methods: Forty-seven acutely hospitalized patients with advanced PD were assessed at baseline (T1) and at the end (T2) of a 2-week early rehabilitative geriatric complex treatment (ERGCT). Global cognitive performance (Montreal Cognitive Assessment, MoCA), EF and divided attention (Trail Making Test B minus A, delta TMT), depressive symptoms, and fear of falling were assessed at T1. Change in walking performance was determined by the difference in quantitative walking parameters extracted from a sensor-based movement analysis over 20 m straight walking in single (ST, fast and normal pace) and dual task (DT, with secondary cognitive, respectively, motor task) conditions between T1 and T2. Bayesian regression (using Bayes Factor BF Results: Under ST, there was moderate evidence (BF Discussion: Our results indicate that the effect of ERGT on change in walking performance is limited for patients with deficits in EF and divided attention. However, these patients also seem to walk more cautiously after treatment in walking situations with additional cognitive demand. Therefore, future development of individualized treatment algorithms is required, which address individual needs of these vulnerable patients.
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